Abstract
The aim of this study was to assess the use of a commercial nano-focused x-ray tomography system to non-invasively investigate the three-dimensional structure of various solid pharmaceutical products. Special emphasis was given to sizing, the quantification of internal voids and the characterization of formulated samples.
| Original language | English |
|---|---|
| Pages | 2-5 |
| Number of pages | 4 |
| Publication status | Published - 14 Jun 2017 |
| Event | Bruker micro-CT User Meeting - Brussel, Belgium Duration: 12 Jun 2017 → 15 Jun 2017 https://www.bruker.com/events/users-meetings/microct/2017.html |
Conference
| Conference | Bruker micro-CT User Meeting |
|---|---|
| Country | Belgium |
| City | Brussel |
| Period | 12/06/17 → 15/06/17 |
| Internet address |
Fingerprint
Keywords
- X-ray tomography
- morphology
- pharmaceutical products
Cite this
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Morphological characterisation of solid pharmaceutical products using X-ray tomography. / Doerr, Frederik; Brammer, Elanor; Wood, Sarahjane; Halbert, Gavin; Florence, Alastair.
2017. 2-5 Bruker micro-CT User Meeting, Brussel, Belgium.Research output: Contribution to conference › Speech
TY - CONF
T1 - Morphological characterisation of solid pharmaceutical products using X-ray tomography
AU - Doerr, Frederik
AU - Brammer, Elanor
AU - Wood, Sarahjane
AU - Halbert, Gavin
AU - Florence, Alastair
PY - 2017/6/14
Y1 - 2017/6/14
N2 - Aims : The measurement of morphological descriptors is widely applied in the pharmaceutical industry to evaluate (intermediate) solid forms in terms of their critical quality attributes that influence product-handling in the manufacturing process or to allow a prediction of the performance of the final dosage form. Previous publications have demonstrated the use of micro-focused tomography to analyze formulations and relate the product performance to structure and sample homogeneity.The aim of this study was to assess the use of a commercial nano-focused x-ray tomography system to non-invasively investigate the three-dimensional structure of various solid pharmaceutical products. Special emphasis was given to sizing, the quantification of internal voids and the characterization of formulated samples.
AB - Aims : The measurement of morphological descriptors is widely applied in the pharmaceutical industry to evaluate (intermediate) solid forms in terms of their critical quality attributes that influence product-handling in the manufacturing process or to allow a prediction of the performance of the final dosage form. Previous publications have demonstrated the use of micro-focused tomography to analyze formulations and relate the product performance to structure and sample homogeneity.The aim of this study was to assess the use of a commercial nano-focused x-ray tomography system to non-invasively investigate the three-dimensional structure of various solid pharmaceutical products. Special emphasis was given to sizing, the quantification of internal voids and the characterization of formulated samples.
KW - X-ray tomography
KW - morphology
KW - pharmaceutical products
M3 - Speech
SP - 2
EP - 5
ER -