Morphological characterisation of solid pharmaceutical products using X-ray tomography

Frederik Doerr; Elanor Brammer; Sarahjane Wood; Gavin Halbert; Alastair Florence

Morphological characterisation of solid pharmaceutical products using X-ray tomography

Frederik Doerr, Elanor Brammer, Sarahjane Wood, Gavin Halbert, Alastair Florence

Research output: Contribution to conference › Speech

11 Downloads (Pure)

Abstract

The measurement of morphological descriptors is widely applied in the pharmaceutical industry to evaluate (intermediate) solid forms in terms of their critical quality attributes that influence product-handling in the manufacturing process or to allow a prediction of the performance of the final dosage form. Previous publications have demonstrated the use of micro-focused tomography to analyze formulations and relate the product performance to structure and sample homogeneity.
The aim of this study was to assess the use of a commercial nano-focused x-ray tomography system to non-invasively investigate the three-dimensional structure of various solid pharmaceutical products. Special emphasis was given to sizing, the quantification of internal voids and the characterization of formulated samples.

Original language	English
Pages	2-5
Number of pages	4
Publication status	Published - 14 Jun 2017
Event	Bruker micro-CT User Meeting - Brussel, Belgium Duration: 12 Jun 2017 → 15 Jun 2017 https://www.bruker.com/events/users-meetings/microct/2017.html

Conference

Conference	Bruker micro-CT User Meeting
Country	Belgium
City	Brussel
Period	12/06/17 → 15/06/17
Internet address	https://www.bruker.com/events/users-meetings/microct/2017.html

Keywords

X-ray tomography
morphology
pharmaceutical products

Access to Document

Doerr-etal-Bruker-2017-Morphological-characterisation-of-solid-pharmaceutical-products-usingAccepted author manuscript, 392 KB
Doerr-etal-Bruker-2017-Morphological-characterisation-of-solid-pharmaceutical-products-using-X-rayFinal published version, 3.16 MB

1 Article

Quantitative investigation of particle formation of a model pharmaceutical formulation using single droplet evaporation experiments and X-ray tomography
Doerr, F. J. S., Oswald, I. D. H. & Florence, A. J., 1 Dec 2018, In: Advanced Powder Technology. 29, 12, p. 2996-3006 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
5 Citations (Scopus)

10 Downloads (Pure)

Cite this

@conference{0ecec7185a174d37b60b2b9412729037,

title = "Morphological characterisation of solid pharmaceutical products using X-ray tomography",

abstract = "The measurement of morphological descriptors is widely applied in the pharmaceutical industry to evaluate (intermediate) solid forms in terms of their critical quality attributes that influence product-handling in the manufacturing process or to allow a prediction of the performance of the final dosage form. Previous publications have demonstrated the use of micro-focused tomography to analyze formulations and relate the product performance to structure and sample homogeneity.The aim of this study was to assess the use of a commercial nano-focused x-ray tomography system to non-invasively investigate the three-dimensional structure of various solid pharmaceutical products. Special emphasis was given to sizing, the quantification of internal voids and the characterization of formulated samples.",

keywords = "X-ray tomography, morphology, pharmaceutical products",

author = "Frederik Doerr and Elanor Brammer and Sarahjane Wood and Gavin Halbert and Alastair Florence",

year = "2017",

month = jun,

day = "14",

language = "English",

pages = "2--5",

note = "Bruker micro-CT User Meeting ; Conference date: 12-06-2017 Through 15-06-2017",

url = "https://www.bruker.com/events/users-meetings/microct/2017.html",

}

TY - CONF

T1 - Morphological characterisation of solid pharmaceutical products using X-ray tomography

AU - Doerr, Frederik

AU - Brammer, Elanor

AU - Wood, Sarahjane

AU - Halbert, Gavin

AU - Florence, Alastair

PY - 2017/6/14

Y1 - 2017/6/14

N2 - The measurement of morphological descriptors is widely applied in the pharmaceutical industry to evaluate (intermediate) solid forms in terms of their critical quality attributes that influence product-handling in the manufacturing process or to allow a prediction of the performance of the final dosage form. Previous publications have demonstrated the use of micro-focused tomography to analyze formulations and relate the product performance to structure and sample homogeneity.The aim of this study was to assess the use of a commercial nano-focused x-ray tomography system to non-invasively investigate the three-dimensional structure of various solid pharmaceutical products. Special emphasis was given to sizing, the quantification of internal voids and the characterization of formulated samples.

AB - The measurement of morphological descriptors is widely applied in the pharmaceutical industry to evaluate (intermediate) solid forms in terms of their critical quality attributes that influence product-handling in the manufacturing process or to allow a prediction of the performance of the final dosage form. Previous publications have demonstrated the use of micro-focused tomography to analyze formulations and relate the product performance to structure and sample homogeneity.The aim of this study was to assess the use of a commercial nano-focused x-ray tomography system to non-invasively investigate the three-dimensional structure of various solid pharmaceutical products. Special emphasis was given to sizing, the quantification of internal voids and the characterization of formulated samples.

KW - X-ray tomography

KW - morphology

KW - pharmaceutical products

M3 - Speech

SP - 2

EP - 5

T2 - Bruker micro-CT User Meeting

Y2 - 12 June 2017 through 15 June 2017

ER -

Morphological characterisation of solid pharmaceutical products using X-ray tomography

Abstract

Conference

Keywords

Access to Document

Quantitative investigation of particle formation of a model pharmaceutical formulation using single droplet evaporation experiments and X-ray tomography

Cite this