Morphological characterisation of solid pharmaceutical products using X-ray tomography

Frederik Doerr; Elanor Brammer; Sarahjane Wood; Gavin Halbert; Alastair Florence

Morphological characterisation of solid pharmaceutical products using X-ray tomography

Frederik Doerr, Elanor Brammer, Sarahjane Wood, Gavin Halbert, Alastair Florence

Research output: Contribution to conference › Speech

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Abstract

The measurement of morphological descriptors is widely applied in the pharmaceutical industry to evaluate (intermediate) solid forms in terms of their critical quality attributes that influence product-handling in the manufacturing process or to allow a prediction of the performance of the final dosage form. Previous publications have demonstrated the use of micro-focused tomography to analyze formulations and relate the product performance to structure and sample homogeneity.
The aim of this study was to assess the use of a commercial nano-focused x-ray tomography system to non-invasively investigate the three-dimensional structure of various solid pharmaceutical products. Special emphasis was given to sizing, the quantification of internal voids and the characterization of formulated samples.

Original language	English
Pages	2-5
Number of pages	4
Publication status	Published - 14 Jun 2017
Event	Bruker micro-CT User Meeting - Brussel, Belgium Duration: 12 Jun 2017 → 15 Jun 2017 https://www.bruker.com/events/users-meetings/microct/2017.html

Conference

Conference	Bruker micro-CT User Meeting
Country/Territory	Belgium
City	Brussel
Period	12/06/17 → 15/06/17
Internet address	https://www.bruker.com/events/users-meetings/microct/2017.html

Keywords

X-ray tomography
morphology
pharmaceutical products

Access to Document

Doerr-etal-Bruker-2017-Morphological-characterisation-of-solid-pharmaceutical-products-usingAccepted author manuscript, 392 KB
Doerr-etal-Bruker-2017-Morphological-characterisation-of-solid-pharmaceutical-products-using-X-rayFinal published version, 3.16 MB

1 Article

Quantitative investigation of particle formation of a model pharmaceutical formulation using single droplet evaporation experiments and X-ray tomography
Doerr, F. J. S., Oswald, I. D. H. & Florence, A. J., 1 Dec 2018, In: Advanced Powder Technology. 29, 12, p. 2996-3006 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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6 Citations (Scopus)

11 Downloads (Pure)

Cite this

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title = "Morphological characterisation of solid pharmaceutical products using X-ray tomography",

abstract = "The measurement of morphological descriptors is widely applied in the pharmaceutical industry to evaluate (intermediate) solid forms in terms of their critical quality attributes that influence product-handling in the manufacturing process or to allow a prediction of the performance of the final dosage form. Previous publications have demonstrated the use of micro-focused tomography to analyze formulations and relate the product performance to structure and sample homogeneity.The aim of this study was to assess the use of a commercial nano-focused x-ray tomography system to non-invasively investigate the three-dimensional structure of various solid pharmaceutical products. Special emphasis was given to sizing, the quantification of internal voids and the characterization of formulated samples.",

keywords = "X-ray tomography, morphology, pharmaceutical products",

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T1 - Morphological characterisation of solid pharmaceutical products using X-ray tomography

AU - Doerr, Frederik

AU - Brammer, Elanor

AU - Wood, Sarahjane

AU - Halbert, Gavin

AU - Florence, Alastair

PY - 2017/6/14

Y1 - 2017/6/14

N2 - The measurement of morphological descriptors is widely applied in the pharmaceutical industry to evaluate (intermediate) solid forms in terms of their critical quality attributes that influence product-handling in the manufacturing process or to allow a prediction of the performance of the final dosage form. Previous publications have demonstrated the use of micro-focused tomography to analyze formulations and relate the product performance to structure and sample homogeneity.The aim of this study was to assess the use of a commercial nano-focused x-ray tomography system to non-invasively investigate the three-dimensional structure of various solid pharmaceutical products. Special emphasis was given to sizing, the quantification of internal voids and the characterization of formulated samples.

AB - The measurement of morphological descriptors is widely applied in the pharmaceutical industry to evaluate (intermediate) solid forms in terms of their critical quality attributes that influence product-handling in the manufacturing process or to allow a prediction of the performance of the final dosage form. Previous publications have demonstrated the use of micro-focused tomography to analyze formulations and relate the product performance to structure and sample homogeneity.The aim of this study was to assess the use of a commercial nano-focused x-ray tomography system to non-invasively investigate the three-dimensional structure of various solid pharmaceutical products. Special emphasis was given to sizing, the quantification of internal voids and the characterization of formulated samples.

KW - X-ray tomography

KW - morphology

KW - pharmaceutical products

M3 - Speech

SP - 2

EP - 5

T2 - Bruker micro-CT User Meeting

Y2 - 12 June 2017 through 15 June 2017

ER -

Morphological characterisation of solid pharmaceutical products using X-ray tomography

Abstract

Conference

Keywords

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Research output

Quantitative investigation of particle formation of a model pharmaceutical formulation using single droplet evaporation experiments and X-ray tomography

Cite this