Morphological characterisation of solid pharmaceutical products using X-ray tomography

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The measurement of morphological descriptors is widely applied in the pharmaceutical industry to evaluate (intermediate) solid forms in terms of their critical quality attributes that influence product-handling in the manufacturing process or to allow a prediction of the performance of the final dosage form. Previous publications have demonstrated the use of micro-focused tomography to analyze formulations and relate the product performance to structure and sample homogeneity.
The aim of this study was to assess the use of a commercial nano-focused x-ray tomography system to non-invasively investigate the three-dimensional structure of various solid pharmaceutical products. Special emphasis was given to sizing, the quantification of internal voids and the characterization of formulated samples.
Original languageEnglish
Number of pages4
Publication statusPublished - 14 Jun 2017
EventBruker micro-CT User Meeting - Brussel, Belgium
Duration: 12 Jun 201715 Jun 2017


ConferenceBruker micro-CT User Meeting
Internet address


  • X-ray tomography
  • morphology
  • pharmaceutical products


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