Morphological characterisation of solid pharmaceutical products using X-ray tomography

Research output: Contribution to conferenceSpeech

Abstract

Aims : The measurement of morphological descriptors is widely applied in the pharmaceutical industry to evaluate (intermediate) solid forms in terms of their critical quality attributes that influence product-handling in the manufacturing process or to allow a prediction of the performance of the final dosage form. Previous publications have demonstrated the use of micro-focused tomography to analyze formulations and relate the product performance to structure and sample homogeneity.
The aim of this study was to assess the use of a commercial nano-focused x-ray tomography system to non-invasively investigate the three-dimensional structure of various solid pharmaceutical products. Special emphasis was given to sizing, the quantification of internal voids and the characterization of formulated samples.
Original languageEnglish
Pages2-5
Number of pages4
Publication statusPublished - 14 Jun 2017
EventBruker micro-CT User Meeting - Brussel, Belgium
Duration: 12 Jun 201715 Jun 2017
https://www.bruker.com/events/users-meetings/microct/2017.html

Conference

ConferenceBruker micro-CT User Meeting
CountryBelgium
CityBrussel
Period12/06/1715/06/17
Internet address

Fingerprint

X Ray Tomography
Tomography
Dosage Forms
Drug Industry
Pharmaceutical Preparations
X-Rays

Keywords

  • X-ray tomography
  • morphology
  • pharmaceutical products

Cite this

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title = "Morphological characterisation of solid pharmaceutical products using X-ray tomography",
abstract = "Aims : The measurement of morphological descriptors is widely applied in the pharmaceutical industry to evaluate (intermediate) solid forms in terms of their critical quality attributes that influence product-handling in the manufacturing process or to allow a prediction of the performance of the final dosage form. Previous publications have demonstrated the use of micro-focused tomography to analyze formulations and relate the product performance to structure and sample homogeneity.The aim of this study was to assess the use of a commercial nano-focused x-ray tomography system to non-invasively investigate the three-dimensional structure of various solid pharmaceutical products. Special emphasis was given to sizing, the quantification of internal voids and the characterization of formulated samples.",
keywords = "X-ray tomography, morphology, pharmaceutical products",
author = "Frederik Doerr and Elanor Brammer and Sarahjane Wood and Gavin Halbert and Alastair Florence",
year = "2017",
month = "6",
day = "14",
language = "English",
pages = "2--5",
note = "Bruker micro-CT User Meeting ; Conference date: 12-06-2017 Through 15-06-2017",
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Doerr, F, Brammer, E, Wood, S, Halbert, G & Florence, A 2017, 'Morphological characterisation of solid pharmaceutical products using X-ray tomography' Bruker micro-CT User Meeting, Brussel, Belgium, 12/06/17 - 15/06/17, pp. 2-5.

Morphological characterisation of solid pharmaceutical products using X-ray tomography. / Doerr, Frederik; Brammer, Elanor; Wood, Sarahjane; Halbert, Gavin; Florence, Alastair.

2017. 2-5 Bruker micro-CT User Meeting, Brussel, Belgium.

Research output: Contribution to conferenceSpeech

TY - CONF

T1 - Morphological characterisation of solid pharmaceutical products using X-ray tomography

AU - Doerr, Frederik

AU - Brammer, Elanor

AU - Wood, Sarahjane

AU - Halbert, Gavin

AU - Florence, Alastair

PY - 2017/6/14

Y1 - 2017/6/14

N2 - Aims : The measurement of morphological descriptors is widely applied in the pharmaceutical industry to evaluate (intermediate) solid forms in terms of their critical quality attributes that influence product-handling in the manufacturing process or to allow a prediction of the performance of the final dosage form. Previous publications have demonstrated the use of micro-focused tomography to analyze formulations and relate the product performance to structure and sample homogeneity.The aim of this study was to assess the use of a commercial nano-focused x-ray tomography system to non-invasively investigate the three-dimensional structure of various solid pharmaceutical products. Special emphasis was given to sizing, the quantification of internal voids and the characterization of formulated samples.

AB - Aims : The measurement of morphological descriptors is widely applied in the pharmaceutical industry to evaluate (intermediate) solid forms in terms of their critical quality attributes that influence product-handling in the manufacturing process or to allow a prediction of the performance of the final dosage form. Previous publications have demonstrated the use of micro-focused tomography to analyze formulations and relate the product performance to structure and sample homogeneity.The aim of this study was to assess the use of a commercial nano-focused x-ray tomography system to non-invasively investigate the three-dimensional structure of various solid pharmaceutical products. Special emphasis was given to sizing, the quantification of internal voids and the characterization of formulated samples.

KW - X-ray tomography

KW - morphology

KW - pharmaceutical products

M3 - Speech

SP - 2

EP - 5

ER -