Morphological characterisation of solid pharmaceutical products using X-ray tomography

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Abstract

The measurement of morphological descriptors is widely applied in the pharmaceutical industry to evaluate (intermediate) solid forms in terms of their critical quality attributes that influence product-handling in the manufacturing process or to allow a prediction of the performance of the final dosage form. Previous publications have demonstrated the use of micro-focused tomography to analyze formulations and relate the product performance to structure and sample homogeneity.
The aim of this study was to assess the use of a commercial nano-focused x-ray tomography system to non-invasively investigate the three-dimensional structure of various solid pharmaceutical products. Special emphasis was given to sizing, the quantification of internal voids and the characterization of formulated samples.
Original languageEnglish
Pages2-5
Number of pages4
Publication statusPublished - 14 Jun 2017
EventBruker micro-CT User Meeting - Brussel, Belgium
Duration: 12 Jun 201715 Jun 2017
https://www.bruker.com/events/users-meetings/microct/2017.html

Conference

ConferenceBruker micro-CT User Meeting
CountryBelgium
CityBrussel
Period12/06/1715/06/17
Internet address

Keywords

  • X-ray tomography
  • morphology
  • pharmaceutical products

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