Monodisperse liquid crystalline peptides

Peter A. G. Cormack, Barry D. Moore, David C. Sherrington

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Solid phase peptide synthesis (SPPS) has been used as a synthetic tool to prepare monodisperse mesogen–oligopeptide conjugates with novel molecular architectures. Building upon previous success in this area, we have extended our methodologies to include a mesogenically substituted l-glutamic acid residue, and incorporated this derivative, as well as the l-lysine derivative previously reported, into a variety of new structures. Some novel liquid crystalline materials have been discovered. Bothalpha;-helical and beta;-sheet secondary structures have been explored as alternative scaffolds for the pendant mesogenic groups. The helical systems show most promise in terms of their ease of synthesis and handling, but at the relatively lower levels of mesogenic substitution studied so far, compared to the previously reported homo-oligopeptide materials, mesophases are not observed. The beta;-sheet materials prepared are rather insoluble and too high melting to have any practical value as thermotropic materials without further manipulation of their structures.
LanguageEnglish
Pages1977-1983
Number of pages7
JournalJournal of Materials Chemistry
Volume7
Issue number10
DOIs
Publication statusPublished - 1997

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Peptides
Oligopeptides
Crystalline materials
Liquids
Derivatives
Liquid Crystals
Scaffolds
Lysine
Glutamic Acid
Melting
Substitution reactions
Acids

Keywords

  • solid phase peptide synthesis
  • monodisperse liquid crystalline peptides
  • liquid crystalline material

Cite this

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Monodisperse liquid crystalline peptides. / Cormack, Peter A. G.; Moore, Barry D.; Sherrington, David C.

In: Journal of Materials Chemistry , Vol. 7, No. 10, 1997, p. 1977-1983.

Research output: Contribution to journalArticle

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AU - Sherrington, David C.

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