Molecularly imprinted solid-phase extraction of cocaine metabolites from aqueous samples

A. Zurutuza, S. Bayoudh, P.A.G. Cormack, L. Dambies, J. Deere, R. Bischoff, D.C. Sherrington

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Cocaine is a well-known drug of abuse which, when ingested nasally or by smoking, undergoes a number of biotransformation and degradation reactions. In the present work, a synthetic analogue of the cocaine metabolite benzoylecgonine was prepared and used as a template molecule in the preparation of a series of molecularly imprinted polymers (MIPs). Molecularly imprinted solid-phase extraction (MISPE) conditions were established under which benzoylecgonine in aqueous samples could be selectively extracted and quantified at clinically relevant concentrations (mu g/ml). Under optimised MISPE conditions, recoveries of analyte were high (> 70%) and excellent discrimination between imprinted and non-imprinted materials observed.
LanguageEnglish
Pages14-19
Number of pages5
JournalAnalytica Chimica Acta
Volume542
Issue number1
DOIs
Publication statusPublished - 22 Jun 2005

Fingerprint

Solid Phase Extraction
Metabolites
Cocaine
metabolite
Street Drugs
biotransformation
Biotransformation
smoking
Polymers
drug
polymer
Smoking
Recovery
Degradation
degradation
Molecules
benzoylecgonine
material

Keywords

  • molecularly imprinted polymers
  • solid-phase extraction
  • cocaine
  • cocaine metabolites
  • benzoylecgonine

Cite this

Zurutuza, A. ; Bayoudh, S. ; Cormack, P.A.G. ; Dambies, L. ; Deere, J. ; Bischoff, R. ; Sherrington, D.C. / Molecularly imprinted solid-phase extraction of cocaine metabolites from aqueous samples. In: Analytica Chimica Acta. 2005 ; Vol. 542, No. 1. pp. 14-19.
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Zurutuza, A, Bayoudh, S, Cormack, PAG, Dambies, L, Deere, J, Bischoff, R & Sherrington, DC 2005, 'Molecularly imprinted solid-phase extraction of cocaine metabolites from aqueous samples' Analytica Chimica Acta, vol. 542, no. 1, pp. 14-19. https://doi.org/10.1016/j.aca.2004.12.019

Molecularly imprinted solid-phase extraction of cocaine metabolites from aqueous samples. / Zurutuza, A.; Bayoudh, S.; Cormack, P.A.G.; Dambies, L.; Deere, J.; Bischoff, R.; Sherrington, D.C.

In: Analytica Chimica Acta, Vol. 542, No. 1, 22.06.2005, p. 14-19.

Research output: Contribution to journalArticle

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KW - molecularly imprinted polymers

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