Molecularly imprinted solid-phase extraction of cocaine metabolites from aqueous samples

A. Zurutuza, S. Bayoudh, P.A.G. Cormack, L. Dambies, J. Deere, R. Bischoff, D.C. Sherrington

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35 Citations (Scopus)

Abstract

Cocaine is a well-known drug of abuse which, when ingested nasally or by smoking, undergoes a number of biotransformation and degradation reactions. In the present work, a synthetic analogue of the cocaine metabolite benzoylecgonine was prepared and used as a template molecule in the preparation of a series of molecularly imprinted polymers (MIPs). Molecularly imprinted solid-phase extraction (MISPE) conditions were established under which benzoylecgonine in aqueous samples could be selectively extracted and quantified at clinically relevant concentrations (mu g/ml). Under optimised MISPE conditions, recoveries of analyte were high (> 70%) and excellent discrimination between imprinted and non-imprinted materials observed.
Original languageEnglish
Pages (from-to)14-19
Number of pages5
JournalAnalytica Chimica Acta
Volume542
Issue number1
DOIs
Publication statusPublished - 22 Jun 2005

Keywords

  • molecularly imprinted polymers
  • solid-phase extraction
  • cocaine
  • cocaine metabolites
  • benzoylecgonine

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