Cocaine is a well-known drug of abuse which, when ingested nasally or by smoking, undergoes a number of biotransformation and degradation reactions. In the present work, a synthetic analogue of the cocaine metabolite benzoylecgonine was prepared and used as a template molecule in the preparation of a series of molecularly imprinted polymers (MIPs). Molecularly imprinted solid-phase extraction (MISPE) conditions were established under which benzoylecgonine in aqueous samples could be selectively extracted and quantified at clinically relevant concentrations (mu g/ml). Under optimised MISPE conditions, recoveries of analyte were high (> 70%) and excellent discrimination between imprinted and non-imprinted materials observed.
- molecularly imprinted polymers
- solid-phase extraction
- cocaine metabolites
Zurutuza, A., Bayoudh, S., Cormack, P. A. G., Dambies, L., Deere, J., Bischoff, R., & Sherrington, D. C. (2005). Molecularly imprinted solid-phase extraction of cocaine metabolites from aqueous samples. Analytica Chimica Acta, 542(1), 14-19. https://doi.org/10.1016/j.aca.2004.12.019