TY - JOUR
T1 - Molecularly imprinted solid-phase extraction of cocaine metabolites from aqueous samples
AU - Zurutuza, A.
AU - Bayoudh, S.
AU - Cormack, P.A.G.
AU - Dambies, L.
AU - Deere, J.
AU - Bischoff, R.
AU - Sherrington, D.C.
PY - 2005/6/22
Y1 - 2005/6/22
N2 - Cocaine is a well-known drug of abuse which, when ingested nasally or by smoking, undergoes a number of biotransformation and degradation reactions. In the present work, a synthetic analogue of the cocaine metabolite benzoylecgonine was prepared and used as a template molecule in the preparation of a series of molecularly imprinted polymers (MIPs). Molecularly imprinted solid-phase extraction (MISPE) conditions were established under which benzoylecgonine in aqueous samples could be selectively extracted and quantified at clinically relevant concentrations (mu g/ml). Under optimised MISPE conditions, recoveries of analyte were high (> 70%) and excellent discrimination between imprinted and non-imprinted materials observed.
AB - Cocaine is a well-known drug of abuse which, when ingested nasally or by smoking, undergoes a number of biotransformation and degradation reactions. In the present work, a synthetic analogue of the cocaine metabolite benzoylecgonine was prepared and used as a template molecule in the preparation of a series of molecularly imprinted polymers (MIPs). Molecularly imprinted solid-phase extraction (MISPE) conditions were established under which benzoylecgonine in aqueous samples could be selectively extracted and quantified at clinically relevant concentrations (mu g/ml). Under optimised MISPE conditions, recoveries of analyte were high (> 70%) and excellent discrimination between imprinted and non-imprinted materials observed.
KW - molecularly imprinted polymers
KW - solid-phase extraction
KW - cocaine
KW - cocaine metabolites
KW - benzoylecgonine
UR - http://dx.doi.org/10.1016/j.aca.2004.12.019
U2 - 10.1016/j.aca.2004.12.019
DO - 10.1016/j.aca.2004.12.019
M3 - Article
VL - 542
SP - 14
EP - 19
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
SN - 0003-2670
IS - 1
ER -