Abstract
Cocaine is a well-known drug of abuse which, when ingested nasally or by smoking, undergoes a number of biotransformation and degradation reactions. In the present work, a synthetic analogue of the cocaine metabolite benzoylecgonine was prepared and used as a template molecule in the preparation of a series of molecularly imprinted polymers (MIPs). Molecularly imprinted solid-phase extraction (MISPE) conditions were established under which benzoylecgonine in aqueous samples could be selectively extracted and quantified at clinically relevant concentrations (mu g/ml). Under optimised MISPE conditions, recoveries of analyte were high (> 70%) and excellent discrimination between imprinted and non-imprinted materials observed.
Original language | English |
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Pages (from-to) | 14-19 |
Number of pages | 5 |
Journal | Analytica Chimica Acta |
Volume | 542 |
Issue number | 1 |
DOIs | |
Publication status | Published - 22 Jun 2005 |
Keywords
- molecularly imprinted polymers
- solid-phase extraction
- cocaine
- cocaine metabolites
- benzoylecgonine