Abstract
| Language | English |
|---|---|
| Pages | 14-19 |
| Number of pages | 5 |
| Journal | Analytica Chimica Acta |
| Volume | 542 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 22 Jun 2005 |
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Keywords
- molecularly imprinted polymers
- solid-phase extraction
- cocaine
- cocaine metabolites
- benzoylecgonine
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Molecularly imprinted solid-phase extraction of cocaine metabolites from aqueous samples. / Zurutuza, A.; Bayoudh, S.; Cormack, P.A.G.; Dambies, L.; Deere, J.; Bischoff, R.; Sherrington, D.C.
In: Analytica Chimica Acta, Vol. 542, No. 1, 22.06.2005, p. 14-19.Research output: Contribution to journal › Article
TY - JOUR
T1 - Molecularly imprinted solid-phase extraction of cocaine metabolites from aqueous samples
AU - Zurutuza, A.
AU - Bayoudh, S.
AU - Cormack, P.A.G.
AU - Dambies, L.
AU - Deere, J.
AU - Bischoff, R.
AU - Sherrington, D.C.
PY - 2005/6/22
Y1 - 2005/6/22
N2 - Cocaine is a well-known drug of abuse which, when ingested nasally or by smoking, undergoes a number of biotransformation and degradation reactions. In the present work, a synthetic analogue of the cocaine metabolite benzoylecgonine was prepared and used as a template molecule in the preparation of a series of molecularly imprinted polymers (MIPs). Molecularly imprinted solid-phase extraction (MISPE) conditions were established under which benzoylecgonine in aqueous samples could be selectively extracted and quantified at clinically relevant concentrations (mu g/ml). Under optimised MISPE conditions, recoveries of analyte were high (> 70%) and excellent discrimination between imprinted and non-imprinted materials observed.
AB - Cocaine is a well-known drug of abuse which, when ingested nasally or by smoking, undergoes a number of biotransformation and degradation reactions. In the present work, a synthetic analogue of the cocaine metabolite benzoylecgonine was prepared and used as a template molecule in the preparation of a series of molecularly imprinted polymers (MIPs). Molecularly imprinted solid-phase extraction (MISPE) conditions were established under which benzoylecgonine in aqueous samples could be selectively extracted and quantified at clinically relevant concentrations (mu g/ml). Under optimised MISPE conditions, recoveries of analyte were high (> 70%) and excellent discrimination between imprinted and non-imprinted materials observed.
KW - molecularly imprinted polymers
KW - solid-phase extraction
KW - cocaine
KW - cocaine metabolites
KW - benzoylecgonine
UR - http://dx.doi.org/10.1016/j.aca.2004.12.019
U2 - 10.1016/j.aca.2004.12.019
DO - 10.1016/j.aca.2004.12.019
M3 - Article
VL - 542
SP - 14
EP - 19
JO - Analytica Chimica Acta
T2 - Analytica Chimica Acta
JF - Analytica Chimica Acta
SN - 0003-2670
IS - 1
ER -