Molecularly imprinted polymer synthesis using RAFT polymerisation

Peter Cormack, Faizatul Shimal Binti Mehamod

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In this paper, the synthesis and characterisation of caffeine-imprinted polymers are described. The polymers were prepared in monolithic form via both reversible addition-fragmentation chain-transfer (RAFT) polymerisation and conventional free radical polymerisation, using methacrylic acid and ethylene glycol dimethacrylate as the functional monomer and crosslinking agent, respectively. The potential benefits in applying RAFT polymerisation techniques towards the synthesis of molecularly imprinted polymers (MIPs) are explored and elucidated. The pore structures of the polymers produced were characterised by nitrogen sorption porosimetry and the molecular recognition properties of representative products were evaluated in high-performance liquid chromatography (HPLC) mode. Molecular imprinting effects were confirmed by analysing the relative retentions of analytes on imprinted and non-imprinted HPLC stationary phases. It was found that a caffeine-imprinted polymer synthesised by RAFT polymerisation was superior to a polymer prepared using a conventional synthetic approach; the imprinting factor and column efficiency were found to be higher for the former material
LanguageEnglish
Pages529-535
Number of pages7
JournalSains Malaysina
Volume42
Issue number4
Publication statusPublished - Apr 2013

Fingerprint

Polymers
Polymerization
High performance liquid chromatography
Caffeine
Molecular recognition
Pore structure
Free radical polymerization
Crosslinking
Sorption
Nitrogen
Monomers

Keywords

  • caffeine
  • molecular recognition
  • molecularly imprinted polymers
  • novel stationary phases
  • RAFT polymerisation

Cite this

Cormack, Peter ; Mehamod, Faizatul Shimal Binti. / Molecularly imprinted polymer synthesis using RAFT polymerisation. In: Sains Malaysina . 2013 ; Vol. 42, No. 4. pp. 529-535.
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Molecularly imprinted polymer synthesis using RAFT polymerisation. / Cormack, Peter; Mehamod, Faizatul Shimal Binti.

In: Sains Malaysina , Vol. 42, No. 4, 04.2013, p. 529-535.

Research output: Contribution to journalArticle

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AU - Mehamod, Faizatul Shimal Binti

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AB - In this paper, the synthesis and characterisation of caffeine-imprinted polymers are described. The polymers were prepared in monolithic form via both reversible addition-fragmentation chain-transfer (RAFT) polymerisation and conventional free radical polymerisation, using methacrylic acid and ethylene glycol dimethacrylate as the functional monomer and crosslinking agent, respectively. The potential benefits in applying RAFT polymerisation techniques towards the synthesis of molecularly imprinted polymers (MIPs) are explored and elucidated. The pore structures of the polymers produced were characterised by nitrogen sorption porosimetry and the molecular recognition properties of representative products were evaluated in high-performance liquid chromatography (HPLC) mode. Molecular imprinting effects were confirmed by analysing the relative retentions of analytes on imprinted and non-imprinted HPLC stationary phases. It was found that a caffeine-imprinted polymer synthesised by RAFT polymerisation was superior to a polymer prepared using a conventional synthetic approach; the imprinting factor and column efficiency were found to be higher for the former material

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