Molecular modelling and cytotoxicity of substituted anthraquinonesas inhibitors of human telomerase

D. Cairns, E. Michalitsi, T.C. Jenkins, S.P. Mackay

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Molecular modelling has been carried out for a number of amine-functionalised anthraquinone derivatives to determine their extent of binding to G-tetraplex DNA and their ability to inhibit the enzymes telomerase and Taq polymerase. The results are compared to data obtained from a modified TRAP assay and show good correlation between the two methods. The findings suggest that anthraquinone derivatives of this type inhibit telomerase by stabilisation of four-stranded tetraplex structures associated with guanine-rich telomeric DNA regions.
Original languageEnglish
Pages (from-to)803-807
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume10
DOIs
Publication statusPublished - 2002

Keywords

  • cytotoxicity
  • molecular modelling
  • human telomerase

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