Molecular mechanisms of platelet P2Y(12) receptor regulation

Margaret R Cunningham, Shaista P Nisar, Stuart J Mundell

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Platelets are critical for haemostasis, however inappropriate activation can lead to the development of arterial thrombosis, which can result in heart attack and stroke. ADP is a key platelet agonist that exerts its actions via stimulation of two surface GPCRs (G-protein-coupled receptors), P2Y(1) and P2Y(12). Similar to most GPCRs, P2Y receptor activity is tightly regulated by a number of complex mechanisms including receptor desensitization, internalization and recycling. In the present article, we review the molecular mechanisms that underlie P2Y(1) and P2Y(12) receptor regulation, with particular emphasis on the structural motifs within the P2Y(12) receptor, which are required to maintain regulatory protein interaction. The implications of these findings for platelet responsiveness are also discussed.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalBiochemical Society Transactions
Volume41
Issue number1
DOIs
Publication statusPublished - 1 Feb 2013

Keywords

  • amino acid sequence
  • blood platelets
  • endocytosis
  • humans
  • molecular sequence data
  • receptors, purinergic P2Y12

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