Molecular imprinting on microgel spheres

Lei Ye, Peter A. G. Cormack, Klaus Mosbach

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

Molecularly imprinted polymers have been prepared in various configurations including, for example, polymer beads, monoliths and membranes for different applications. The most common form of imprinted polymer is, however, still the irregularly shaped particle obtained by grinding the traditional, macroporous polymer monolith. We herein present a novel and efficient approach leading to imprinted microspheres, i.e. microgels bearing binding sites specific to target molecules. Imprinted microgels are proposed to be the basic components in previously reported, molecularly imprinted, cross-linked polymers, although the polymers themselves may exist in different forms depending on the preparation method utilised. Chemical modification of the molecularly imprinted microspheres introduces additional functionalities that may be used to couple sensing elements in various assay formats, or for the immobilisation of the imprinted microspheres on various transducers towards the development of biomimetic sensors.
LanguageEnglish
Pages187-196
Number of pages10
JournalAnalytica Chimica Acta
Volume435
Early online date15 May 2001
DOIs
Publication statusPublished - 2001

Fingerprint

Molecular Imprinting
imprinting
Polymers
polymer
Microspheres
Bearings (structural)
Biomimetics
Chemical modification
Binding sites
transducer
grinding
Transducers
Immobilization
immobilization
Assays
Binding Sites
assay
membrane
sensor
Membranes

Keywords

  • molecular imprinting
  • microgel
  • precipitation polymerisation
  • theophylline
  • 17β-estradiol

Cite this

Ye, Lei ; Cormack, Peter A. G. ; Mosbach, Klaus. / Molecular imprinting on microgel spheres. In: Analytica Chimica Acta. 2001 ; Vol. 435. pp. 187-196.
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Molecular imprinting on microgel spheres. / Ye, Lei; Cormack, Peter A. G.; Mosbach, Klaus.

In: Analytica Chimica Acta, Vol. 435, 2001, p. 187-196.

Research output: Contribution to journalArticle

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