Molecular dynamics study of the interaction of a shock wave with a biological membrane

J. Lechuga, D. Drikakis, S. Pal

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

This paper presents a computational study of the interaction of a shock wave with a biological membrane. The membrane model comprises 21 555 atoms which build 66 dalmitoyloleoylphosphatidylcholine (POPC) lipids forming the bilayer, and 4237 water molecules, with the distance between the layers being set to fit around the actual membrane thickness (54 Å), and the lattice period being set to fit the actual surface density of lipid molecules. We have employed a molecular dynamics method for solving the Newton equations of motion numerically thereby providing a strategy to understand the basic physics of the biological structure at atomistic level. A shock wave has been modelled as an impulse of 40 Pa s, and simulations for the interaction of the shock wave with the membrane have been performed for 200 ps to investigate the different effects of the shock wave on different membrane properties including thickness, area, volume, order parameter and lateral diffusion.
Original languageEnglish
Pages (from-to)677-692
Number of pages16
JournalInternational Journal for Numerical Methods in Fluids
Volume57
Issue number5
DOIs
Publication statusPublished - 28 Jun 2008

Keywords

  • shock wave
  • biological membrane
  • molecular dynamics
  • diffusion
  • mass transport
  • nanoscience

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