Molecular determinants in pulmonary hypertension: the role of PDE5

N.J. Pyne, Fiona Murray, R. Tate, Margaret R MacLean

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)


This chapter discusses molecular determinants in pulmonary hypertension. Role of PDE5
Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an integrated volume covering PDE biology from genes to organisms. It examines phosphodiesterases as pharmacological targets as well as the development of specific PDE inhibitors as therapeutic agents. With contributions from pioneers in the field, individual chapters describe one of the 11 known mammalian PDE families including the molecular characteristics, structure, function, and traits unique to each.
Original languageEnglish
Title of host publicationCyclic Nucleotide Phosphodiesterases in Health and Diseases
EditorsJ Beavo, S Francis, MD Houslay
Place of PublicationBoca Raton
Number of pages18
Publication statusPublished - 2006


  • pulmonary hypertension
  • PDE5
  • cyclic nucleotide phosphodiesterases

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