Molecular determinants in pulmonary hypertension: the role of PDE5

N.J. Pyne, Fiona Murray, R. Tate, Margaret R MacLean

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract

This chapter discusses molecular determinants in pulmonary hypertension. Role of PDE5
Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an integrated volume covering PDE biology from genes to organisms. It examines phosphodiesterases as pharmacological targets as well as the development of specific PDE inhibitors as therapeutic agents. With contributions from pioneers in the field, individual chapters describe one of the 11 known mammalian PDE families including the molecular characteristics, structure, function, and traits unique to each.
LanguageEnglish
Title of host publicationCyclic Nucleotide Phosphodiesterases in Health and Diseases
EditorsJ Beavo, S Francis, MD Houslay
Place of PublicationBoca Raton
Pages501-518
Number of pages18
DOIs
Publication statusPublished - 2006

Fingerprint

Phosphoric Diester Hydrolases
Pulmonary Hypertension
Molecular Structure
Nucleotides
Pharmacology
Health
Genes
Therapeutics

Keywords

  • pulmonary hypertension
  • PDE5
  • cyclic nucleotide phosphodiesterases

Cite this

Pyne, N. J., Murray, F., Tate, R., & MacLean, M. R. (2006). Molecular determinants in pulmonary hypertension: the role of PDE5. In J. Beavo, S. Francis, & MD. Houslay (Eds.), Cyclic Nucleotide Phosphodiesterases in Health and Diseases (pp. 501-518). Boca Raton. https://doi.org/10.1201/9781420020847.ch25
Pyne, N.J. ; Murray, Fiona ; Tate, R. ; MacLean, Margaret R. / Molecular determinants in pulmonary hypertension : the role of PDE5. Cyclic Nucleotide Phosphodiesterases in Health and Diseases. editor / J Beavo ; S Francis ; MD Houslay. Boca Raton, 2006. pp. 501-518
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Pyne, NJ, Murray, F, Tate, R & MacLean, MR 2006, Molecular determinants in pulmonary hypertension: the role of PDE5. in J Beavo, S Francis & MD Houslay (eds), Cyclic Nucleotide Phosphodiesterases in Health and Diseases. Boca Raton, pp. 501-518. https://doi.org/10.1201/9781420020847.ch25

Molecular determinants in pulmonary hypertension : the role of PDE5. / Pyne, N.J.; Murray, Fiona; Tate, R.; MacLean, Margaret R.

Cyclic Nucleotide Phosphodiesterases in Health and Diseases. ed. / J Beavo; S Francis; MD Houslay. Boca Raton, 2006. p. 501-518.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

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Pyne NJ, Murray F, Tate R, MacLean MR. Molecular determinants in pulmonary hypertension: the role of PDE5. In Beavo J, Francis S, Houslay MD, editors, Cyclic Nucleotide Phosphodiesterases in Health and Diseases. Boca Raton. 2006. p. 501-518 https://doi.org/10.1201/9781420020847.ch25