Activities per year
Abstract
Material systems that can be used to flexibly and precisely define the chemical nature and molecular arrangement of a surface would be invaluable for the control of complex biointerfacial interactions. For example, progress in antifouling polymer biointerfaces that prevents nonspecific protein adsorption and cell attachment, which can significantly improve the performance of an array of biomedical and industrial applications, is hampered by a lack of chemical models to identify the molecular features conferring their properties. Poly(N-substituted glycine) “pep- toids” are peptidomimetic polymers that can be conveniently synthesized with specific monomer sequences and chain lengths, and are presented as a versatile platform for investigating the molecular design of antifouling polymer brushes. Zwitterionic antifouling polymer brushes have captured significant recent atten- tion, and a targeted library of zwitterionic peptoid brushes with different charge densities, hydration, separations between charged groups, chain lengths, and grafted chain densities, is quantitatively evaluated for their antifouling properties through a range of protein adsorption and cell attachment assays. Specific zwit- terionic brush designs are found to give rise to distinct but subtle differences in properties. The results also point to the dominant roles of the grafted chain density and chain length in determining the performance of antifouling polymer brushes.
Original language | English |
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Article number | 1400225 |
Number of pages | 10 |
Journal | Advanced Materials Interfaces |
Volume | 2 |
Issue number | 1 |
Early online date | 26 Nov 2014 |
DOIs | |
Publication status | Published - 7 Jan 2015 |
Keywords
- biointerface
- protein and cell surface interactions
- zwitterionic polymer brush
- surface modification
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Dive into the research topics of 'Molecular design of antifouling polymer brushes using sequence-specific peptoids'. Together they form a unique fingerprint.Profiles
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4th London Polymer Group Symposium
Lau, K. H. A. (Invited speaker)
14 Nov 2018Activity: Participating in or organising an event types › Participation in conference
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10th Peptoid Summit
Lau, K. H. A. (Invited speaker)
11 Aug 2018Activity: Participating in or organising an event types › Participation in conference
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Invited Seminar in the Department of Materials Science and Engineering, UC Berkeley
Lau, K. H. A. (Invited speaker)
8 Aug 2017Activity: Talk or presentation types › Invited talk