Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds

Fiona L. Henriquez, Paul R. Ingram, Stephen P. Muench, David W. Rice, Craig W. Roberts

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Abstract

Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp. are resistant to five antimicrotubule compounds, unlike any other eukaryote studied so far. Resistance correlates with critical amino acid differences within the inhibitor binding sites of the tubulin heterodimers.
Original languageEnglish
Pages (from-to)1133-1135
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume52
Issue number3
DOIs
Publication statusPublished - Mar 2008

Keywords

  • molecular chemistry
  • acanthamoeba tubulins
  • anti-tubulin compounds
  • pharmacology

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