Molar efficiency

a useful metric to gauge relative reaction efficiency in discovery medicinal chemistry

Fiona I. McGonagle, Helen F. Sneddon, Craig Jamieson, Allan Watson

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The concept of molar efficiency is introduced as a new metric to enable assessment of reaction efficiency in discovery medicinal chemistry. Calculations from molar units enable cross-comparison of the broad range of transformations employed in discovery-phase medicinal chemistry research and is proposed to facilitate identification of more sustainable synthetic transformations.

Original languageEnglish
Pages (from-to)523-532
Number of pages10
JournalACS Sustainable Chemistry and Engineering
Volume2
Issue number3
DOIs
Publication statusPublished - 3 Mar 2014

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Gages
gauge
Pharmaceutical Chemistry
calculation
comparison

Keywords

  • discovery medicinal chemistry
  • reaction efficiency
  • metrics

Cite this

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Molar efficiency : a useful metric to gauge relative reaction efficiency in discovery medicinal chemistry. / McGonagle, Fiona I.; Sneddon, Helen F.; Jamieson, Craig; Watson, Allan.

In: ACS Sustainable Chemistry and Engineering, Vol. 2, No. 3, 03.03.2014, p. 523-532.

Research output: Contribution to journalArticle

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T2 - a useful metric to gauge relative reaction efficiency in discovery medicinal chemistry

AU - McGonagle, Fiona I.

AU - Sneddon, Helen F.

AU - Jamieson, Craig

AU - Watson, Allan

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KW - metrics

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