Modulation of autoimmune and allergic responses by defined nematode molecules

W. Harnett, L. Al-Riyami, J. Rzepecka, M. M. Harnett

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter explores the immunomodulatory effects of nematode infections which protect the host against autoimmune and allergic diseases. Included are discussions on specific nematode molecules (i.e., Ascaris suum PAS-1, cystatins, Dirofilaria immitis-derived antigen (DiAg), galectin-9 homologue of Toxascaris leonina (Tl-GAL), ES-62) that exert immunomodulatory properties in animal studies and their probable mechanisms of action.
Original languageEnglish
Title of host publicationParasitic Nematodes
Subtitle of host publicationMolecular Biology, Biochemistry and Immunology
EditorsM. W. Kennedy, W. Harnett
Pages144-155
Number of pages12
DOIs
Publication statusPublished - 2013

Keywords

  • allergies
  • animal parasitic nematodes
  • autoimmune diseases
  • disease models
  • excretory–secretory products
  • experimental infections
  • helminthoses
  • helminths
  • human disease
  • immune response
  • immunomodulatory properties
  • infections
  • laboratory animals
  • nematode infections
  • parasites
  • parisitoses

Cite this