Modulation of a heterologous immune response by the products of ascaris suum

J.C. Paterson, P. Garside, M.W. Kennedy, C. Lawrence

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Helminth infections are among the most potent stimulators of Th2-type immune responses and have been widely demonstrated to modify responsiveness to both nonparasite antigens and other infectious agents in a nonspecific manner in infected animals. We investigated the immunomodulatory properties of pseudocoelomic body fluid from adult Ascaris suum gastrointestinal helminths (ABF) and its defined allergen (ABA-1) by examining their effects on the immune response to a heterologous antigen, ovalbumin. Our results indicate that ABF has potent immunomodulatory activity and that the effects observed are consistent with skewing towards a Th2-type response rather than induction of anergy. Our findings show that the immunomodulatory activities of ABF are associated with components other than the major constituent and putative allergen, ABA-1. Furthermore, the allergic responses to ABA-1 are not a result of an intrinsic allergenicity of the protein but are more a reflection of the wider induction of a Th2 response by the infection. Importantly, the induction of interleukin-10 by ABF also suggests that T regulatory cells may play a role in immunomodulation of immune responses by parasitic helminths.
Original languageEnglish
Pages (from-to)6058-6067
Number of pages10
JournalInfection and Immunity
Volume70
Issue number11
DOIs
Publication statusPublished - 2002

Keywords

  • helminth infections
  • ascaris suum
  • immune response
  • parasitic helminths

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