Modulation of a heterologous immune response by the products of ascaris suum

J.C. Paterson, P. Garside, M.W. Kennedy, C. Lawrence

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Helminth infections are among the most potent stimulators of Th2-type immune responses and have been widely demonstrated to modify responsiveness to both nonparasite antigens and other infectious agents in a nonspecific manner in infected animals. We investigated the immunomodulatory properties of pseudocoelomic body fluid from adult Ascaris suum gastrointestinal helminths (ABF) and its defined allergen (ABA-1) by examining their effects on the immune response to a heterologous antigen, ovalbumin. Our results indicate that ABF has potent immunomodulatory activity and that the effects observed are consistent with skewing towards a Th2-type response rather than induction of anergy. Our findings show that the immunomodulatory activities of ABF are associated with components other than the major constituent and putative allergen, ABA-1. Furthermore, the allergic responses to ABA-1 are not a result of an intrinsic allergenicity of the protein but are more a reflection of the wider induction of a Th2 response by the infection. Importantly, the induction of interleukin-10 by ABF also suggests that T regulatory cells may play a role in immunomodulation of immune responses by parasitic helminths.
LanguageEnglish
Pages6058-6067
Number of pages10
JournalInfection and Immunity
Volume70
Issue number11
DOIs
Publication statusPublished - 2002

Fingerprint

Ascaris suum
Helminths
Allergens
Heterophile Antigens
Immunomodulation
Ovalbumin
Body Fluids
Regulatory T-Lymphocytes
Infection
Interleukin-10
Antigens
Proteins

Keywords

  • helminth infections
  • ascaris suum
  • immune response
  • parasitic helminths

Cite this

Paterson, J.C. ; Garside, P. ; Kennedy, M.W. ; Lawrence, C. / Modulation of a heterologous immune response by the products of ascaris suum. In: Infection and Immunity. 2002 ; Vol. 70, No. 11. pp. 6058-6067.
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Modulation of a heterologous immune response by the products of ascaris suum. / Paterson, J.C.; Garside, P.; Kennedy, M.W.; Lawrence, C.

In: Infection and Immunity, Vol. 70, No. 11, 2002, p. 6058-6067.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Modulation of a heterologous immune response by the products of ascaris suum

AU - Paterson, J.C.

AU - Garside, P.

AU - Kennedy, M.W.

AU - Lawrence, C.

PY - 2002

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N2 - Helminth infections are among the most potent stimulators of Th2-type immune responses and have been widely demonstrated to modify responsiveness to both nonparasite antigens and other infectious agents in a nonspecific manner in infected animals. We investigated the immunomodulatory properties of pseudocoelomic body fluid from adult Ascaris suum gastrointestinal helminths (ABF) and its defined allergen (ABA-1) by examining their effects on the immune response to a heterologous antigen, ovalbumin. Our results indicate that ABF has potent immunomodulatory activity and that the effects observed are consistent with skewing towards a Th2-type response rather than induction of anergy. Our findings show that the immunomodulatory activities of ABF are associated with components other than the major constituent and putative allergen, ABA-1. Furthermore, the allergic responses to ABA-1 are not a result of an intrinsic allergenicity of the protein but are more a reflection of the wider induction of a Th2 response by the infection. Importantly, the induction of interleukin-10 by ABF also suggests that T regulatory cells may play a role in immunomodulation of immune responses by parasitic helminths.

AB - Helminth infections are among the most potent stimulators of Th2-type immune responses and have been widely demonstrated to modify responsiveness to both nonparasite antigens and other infectious agents in a nonspecific manner in infected animals. We investigated the immunomodulatory properties of pseudocoelomic body fluid from adult Ascaris suum gastrointestinal helminths (ABF) and its defined allergen (ABA-1) by examining their effects on the immune response to a heterologous antigen, ovalbumin. Our results indicate that ABF has potent immunomodulatory activity and that the effects observed are consistent with skewing towards a Th2-type response rather than induction of anergy. Our findings show that the immunomodulatory activities of ABF are associated with components other than the major constituent and putative allergen, ABA-1. Furthermore, the allergic responses to ABA-1 are not a result of an intrinsic allergenicity of the protein but are more a reflection of the wider induction of a Th2 response by the infection. Importantly, the induction of interleukin-10 by ABF also suggests that T regulatory cells may play a role in immunomodulation of immune responses by parasitic helminths.

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