Abstract
| Language | English |
|---|---|
| Pages | 6058-6067 |
| Number of pages | 10 |
| Journal | Infection and Immunity |
| Volume | 70 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- helminth infections
- ascaris suum
- immune response
- parasitic helminths
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Modulation of a heterologous immune response by the products of ascaris suum. / Paterson, J.C.; Garside, P.; Kennedy, M.W.; Lawrence, C.
In: Infection and Immunity, Vol. 70, No. 11, 2002, p. 6058-6067.Research output: Contribution to journal › Article
TY - JOUR
T1 - Modulation of a heterologous immune response by the products of ascaris suum
AU - Paterson, J.C.
AU - Garside, P.
AU - Kennedy, M.W.
AU - Lawrence, C.
PY - 2002
Y1 - 2002
N2 - Helminth infections are among the most potent stimulators of Th2-type immune responses and have been widely demonstrated to modify responsiveness to both nonparasite antigens and other infectious agents in a nonspecific manner in infected animals. We investigated the immunomodulatory properties of pseudocoelomic body fluid from adult Ascaris suum gastrointestinal helminths (ABF) and its defined allergen (ABA-1) by examining their effects on the immune response to a heterologous antigen, ovalbumin. Our results indicate that ABF has potent immunomodulatory activity and that the effects observed are consistent with skewing towards a Th2-type response rather than induction of anergy. Our findings show that the immunomodulatory activities of ABF are associated with components other than the major constituent and putative allergen, ABA-1. Furthermore, the allergic responses to ABA-1 are not a result of an intrinsic allergenicity of the protein but are more a reflection of the wider induction of a Th2 response by the infection. Importantly, the induction of interleukin-10 by ABF also suggests that T regulatory cells may play a role in immunomodulation of immune responses by parasitic helminths.
AB - Helminth infections are among the most potent stimulators of Th2-type immune responses and have been widely demonstrated to modify responsiveness to both nonparasite antigens and other infectious agents in a nonspecific manner in infected animals. We investigated the immunomodulatory properties of pseudocoelomic body fluid from adult Ascaris suum gastrointestinal helminths (ABF) and its defined allergen (ABA-1) by examining their effects on the immune response to a heterologous antigen, ovalbumin. Our results indicate that ABF has potent immunomodulatory activity and that the effects observed are consistent with skewing towards a Th2-type response rather than induction of anergy. Our findings show that the immunomodulatory activities of ABF are associated with components other than the major constituent and putative allergen, ABA-1. Furthermore, the allergic responses to ABA-1 are not a result of an intrinsic allergenicity of the protein but are more a reflection of the wider induction of a Th2 response by the infection. Importantly, the induction of interleukin-10 by ABF also suggests that T regulatory cells may play a role in immunomodulation of immune responses by parasitic helminths.
KW - helminth infections
KW - ascaris suum
KW - immune response
KW - parasitic helminths
U2 - 10.1128/IAI.70.11.6058-6067.2002
DO - 10.1128/IAI.70.11.6058-6067.2002
M3 - Article
VL - 70
SP - 6058
EP - 6067
JO - Infection and Immunity
T2 - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 11
ER -