Abstract
| Language | English |
|---|---|
| Pages | 7189-7198 |
| Number of pages | 9 |
| Journal | Nanoscale |
| Volume | 9 |
| Issue number | 21 |
| Early online date | 8 May 2017 |
| DOIs | |
| Publication status | Published - 1 Jun 2017 |
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Keywords
- drug loaded dendrimersomes
- nanoscale carriers
- dendrimersomes
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Modular synthesis of self-assembling Janus-dendrimers and facile preparation of drug-loaded dendrimersomes. / Nummelin, Sami; Selin, Markus; Legrand, Sacha; Ropponen, Jarmo; Seitsonen, Jani; Nykänen, Antti; Koivisto, Jari; Hirvonen, Jouni; Kostiainen, Mauri A; Bimbo, Luis M.
In: Nanoscale, Vol. 9, No. 21, 01.06.2017, p. 7189-7198.Research output: Contribution to journal › Article
TY - JOUR
T1 - Modular synthesis of self-assembling Janus-dendrimers and facile preparation of drug-loaded dendrimersomes
AU - Nummelin, Sami
AU - Selin, Markus
AU - Legrand, Sacha
AU - Ropponen, Jarmo
AU - Seitsonen, Jani
AU - Nykänen, Antti
AU - Koivisto, Jari
AU - Hirvonen, Jouni
AU - Kostiainen, Mauri A
AU - Bimbo, Luis M.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Materials and methods aimed at the next generation of nanoscale carriers for drugs and other therapeutics are currently in great demand. Yet, creating these precise molecular arrangements in a feasible and straightforward manner represents a remarkable challenge. Herein we report a modular synthetic route for amphiphilic Janus-dendrimers via a copper-catalyzed click reaction (CuAAC) and a facile procedure, using simple injection, to obtain highly uniform dendrimersomes with efficient loading of the model drug compound propranolol. The resulting assemblies were analyzed by dynamic light scattering and cryogenic transmission electronic microscopy revealing the formation of unilamellar and multilamellar dendrimersomes. The formation of a bilayer structure was confirmed using cryo-TEM and confocal microscopy visualization of an encapsulated solvatochromic dye (Nile red). The dendrimersomes reported here are tunable in size, stable over time and display robust thermal stability in aqueous media. Our results expand the scope of dendrimer-based supramolecular colloidal systems and offer the means for one-step fabrication of drug-loaded dendrimersomes in the size range of 90–200 nm, ideal for biomedical applications.
AB - Materials and methods aimed at the next generation of nanoscale carriers for drugs and other therapeutics are currently in great demand. Yet, creating these precise molecular arrangements in a feasible and straightforward manner represents a remarkable challenge. Herein we report a modular synthetic route for amphiphilic Janus-dendrimers via a copper-catalyzed click reaction (CuAAC) and a facile procedure, using simple injection, to obtain highly uniform dendrimersomes with efficient loading of the model drug compound propranolol. The resulting assemblies were analyzed by dynamic light scattering and cryogenic transmission electronic microscopy revealing the formation of unilamellar and multilamellar dendrimersomes. The formation of a bilayer structure was confirmed using cryo-TEM and confocal microscopy visualization of an encapsulated solvatochromic dye (Nile red). The dendrimersomes reported here are tunable in size, stable over time and display robust thermal stability in aqueous media. Our results expand the scope of dendrimer-based supramolecular colloidal systems and offer the means for one-step fabrication of drug-loaded dendrimersomes in the size range of 90–200 nm, ideal for biomedical applications.
KW - drug loaded dendrimersomes
KW - nanoscale carriers
KW - dendrimersomes
U2 - 10.1039/C6NR08102A
DO - 10.1039/C6NR08102A
M3 - Article
VL - 9
SP - 7189
EP - 7198
JO - Nanoscale
T2 - Nanoscale
JF - Nanoscale
SN - 2040-3364
IS - 21
ER -