Projects per year
Two Pd-catalyzed methods to access 6-heteroaryl 2-aminopurine ribonucleosides from 6-chloroguanosine are described. First, Pd-132-catalyzed Suzuki-Miyaura cross-coupling using a series of boron substrates and 6-chloroguanosine forms 6-heteroaryl-2-aminopurines in a single step. The versatility of 6-chloroguanosine is further demonstrated using a modified Sonogashira coupling employing potassium iodide as an additive. Finally, the utility of the 6-alkynyl-2-aminopurine ribonucleoside as a dipolarophile in [3 + 2] cycloadditions is presented, affording triazoles and isoxazoles when reacted with azide and isonitrile 1,3-dipoles, respectively.
- boron substrates
- Sonogashira coupling
- Suzuki−Miyaura cross coupling
1/07/15 → 1/01/20
Project: Research Studentship - Internally Allocated
1/10/14 → 30/09/19
Project: Research - Studentship
Data for "Modular, Step-Efficient Palladium-Catalyzed Cross-Coupling Strategy To Access C6-Heteroaryl 2‑Aminopurine Ribonucleosides"
Buchanan, H. S. (Creator), University of Strathclyde, 18 Jan 2018
Correction to "Modular, step-efficient palladium-catalyzed cross-coupling strategy to access C6-heteroaryl 2-aminopurine ribonucleosides"Buchanan, H. S., Pauff, S. M., Kosmidis, T. D., Taladriz-Sender, A., Rutherford, O. I., Hatit, M. Z. C., Fenner, S., Watson, A. J. B. & Burley, G. A., 2 Aug 2017, In : Organic Letters. 19, 14, 1 p.
Research output: Contribution to journal › ArticleOpen AccessFile26 Downloads (Pure)