Modifying alkylzinc reactivity with 2,2 '-dipyridylamide: activation of tBu-Zn bonds for para-alkylation of benzophenone

David R. Armstrong, Jennifer A. Garden, Alan R. Kennedy, Robert Mulvey, Stuart D. Robertson

Research output: Contribution to journalArticle

13 Citations (Scopus)
38 Downloads (Pure)

Abstract

Undercover agent: Masquerading as a simple donor-acceptor complex (1), sodium amide substoichiometrically activates tBuZn for the challenging 1,6-addition of a tert-butyl group to benzophenone. In contrast, the nonactivated tBuZn is ineffectual.
Original languageEnglish
Pages (from-to)7190-7193
Number of pages4
JournalAngewandte Chemie International Edition
Volume52
Issue number28
Early online date5 Jun 2013
DOIs
Publication statusPublished - 8 Jul 2013

Keywords

  • zinc
  • reagents
  • ligands
  • alkylation
  • metalation
  • alkali metal
  • crystal-structure
  • dipyridylamine
  • chloride
  • 2,2-dipyridylamine
  • sodium TMP-zincate
  • chemistry
  • homogeneous catalysis
  • amides
  • complexes

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