Modifying alkylzinc reactivity with 2,2 '-dipyridylamide: activation of tBu-Zn bonds for para-alkylation of benzophenone

David R. Armstrong, Jennifer A. Garden, Alan R. Kennedy, Robert Mulvey, Stuart D. Robertson

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Undercover agent: Masquerading as a simple donor-acceptor complex (1), sodium amide substoichiometrically activates tBuZn for the challenging 1,6-addition of a tert-butyl group to benzophenone. In contrast, the nonactivated tBuZn is ineffectual.
LanguageEnglish
Pages7190-7193
Number of pages4
JournalAngewandte Chemie International Edition
Volume52
Issue number28
Early online date5 Jun 2013
DOIs
Publication statusPublished - 8 Jul 2013

Fingerprint

Alkylation
Amides
Sodium
Chemical activation
benzophenone

Keywords

  • zinc
  • reagents
  • ligands
  • alkylation
  • metalation
  • alkali metal
  • crystal-structure
  • dipyridylamine
  • chloride
  • 2,2-dipyridylamine
  • sodium TMP-zincate
  • chemistry
  • homogeneous catalysis
  • amides
  • complexes

Cite this

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abstract = "Undercover agent: Masquerading as a simple donor-acceptor complex (1), sodium amide substoichiometrically activates tBuZn for the challenging 1,6-addition of a tert-butyl group to benzophenone. In contrast, the nonactivated tBuZn is ineffectual.",
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Modifying alkylzinc reactivity with 2,2 '-dipyridylamide : activation of tBu-Zn bonds for para-alkylation of benzophenone. / Armstrong, David R.; Garden, Jennifer A.; Kennedy, Alan R.; Mulvey, Robert; Robertson, Stuart D.

In: Angewandte Chemie International Edition, Vol. 52, No. 28, 08.07.2013, p. 7190-7193.

Research output: Contribution to journalArticle

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