Modification of polymer surfaces: optimization of approaches

J.M. Courtney, X.B. Zhao, H. Qian, A. Sharma

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    Modification of polymer surfaces to achieve a surface with enhanced compatibility is an important means of obtaining improved biomaterials. Techniques are available for altering the hydrophilicity or charge of a surface, attaching macromolecules or attempting to resemble cell membranes. Relevant to the clinical success of a modified surface is the modification procedure and a procedure based on incorporation as opposed to surface treatment has potential advantages. The modification of plasticized vinyl chloride (PVC) by the incorporation of cyclodextrins is described. In comparison to unmodified PVC controls, cyclodextrin incorporation reduced fibrinogen adsorption, with the extent of reduction dependent on the type and quantity of cyclodextrin incorporated.
    Original languageEnglish
    Pages (from-to)33-39
    Number of pages6
    JournalPerfusion
    Volume18
    Issue number1
    DOIs
    Publication statusPublished - 2003

    Keywords

    • polymers
    • perfusion
    • hydrophilicity
    • adsorption
    • bioengineering

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