Modelling the swelling of pharmaceutical tablets from single particle understanding using DEM

Mithushan Soundaranathan; Mohammed Al-Sharabi; Thomas Sweijen; Kendal Pitt; J. Axel Zeitler; S Majid Hassanizadeh; Blair Johnston; Daniel Markl

Modelling the swelling of pharmaceutical tablets from single particle understanding using DEM

Mithushan Soundaranathan, Mohammed Al-Sharabi, Thomas Sweijen, Kendal Pitt, J. Axel Zeitler, S Majid Hassanizadeh, Blair Johnston, Daniel Markl

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to conference › Poster

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Abstract

Most tablets are designed to break up into smaller fragments when they come in contact with a physiological fluid in order to accelerate the dissolution of the drug. This break up is caused by the swelling of individual particles in a tablet that leads to the interruption of the interparticulate bonds. This study focused on modelling the swelling of a tablet using discrete element modelling (DEM) paired with a single particle swelling model [1,2] and experimental liquid penetration depth data measured by a flow through cell [3] coupled with a commercial terahertz (THz) system (TeraPulse 4000, Teraview Ltd., UK).

Original language	English
Pages	33-33
Number of pages	1
Publication status	Published - 16 May 2022
Event	CMAC Annual Open Day 2022 - Glasgow, United Kingdom Duration: 16 May 2022 → 18 May 2022

Conference

Conference	CMAC Annual Open Day 2022
Country/Territory	United Kingdom
City	Glasgow
Period	16/05/22 → 18/05/22

Keywords

pharmaceutical tablet swelling
discrete element modeling
single particle model

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Soundaranathan-etal-CMAC-2022-Modelling-the-swelling-of-pharmaceutical-tablets-from-single-particle-understandingFinal published version, 1.31 MBLicence: Strath_1

Cite this

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title = "Modelling the swelling of pharmaceutical tablets from single particle understanding using DEM",

abstract = "Most tablets are designed to break up into smaller fragments when they come in contact with a physiological fluid in order to accelerate the dissolution of the drug. This break up is caused by the swelling of individual particles in a tablet that leads to the interruption of the interparticulate bonds. This study focused on modelling the swelling of a tablet using discrete element modelling (DEM) paired with a single particle swelling model [1,2] and experimental liquid penetration depth data measured by a flow through cell [3] coupled with a commercial terahertz (THz) system (TeraPulse 4000, Teraview Ltd., UK).",

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AU - Soundaranathan, Mithushan

AU - Al-Sharabi, Mohammed

AU - Sweijen, Thomas

AU - Pitt, Kendal

AU - Zeitler, J. Axel

AU - Hassanizadeh, S Majid

AU - Johnston, Blair

AU - Markl, Daniel

PY - 2022/5/16

Y1 - 2022/5/16

N2 - Most tablets are designed to break up into smaller fragments when they come in contact with a physiological fluid in order to accelerate the dissolution of the drug. This break up is caused by the swelling of individual particles in a tablet that leads to the interruption of the interparticulate bonds. This study focused on modelling the swelling of a tablet using discrete element modelling (DEM) paired with a single particle swelling model [1,2] and experimental liquid penetration depth data measured by a flow through cell [3] coupled with a commercial terahertz (THz) system (TeraPulse 4000, Teraview Ltd., UK).

AB - Most tablets are designed to break up into smaller fragments when they come in contact with a physiological fluid in order to accelerate the dissolution of the drug. This break up is caused by the swelling of individual particles in a tablet that leads to the interruption of the interparticulate bonds. This study focused on modelling the swelling of a tablet using discrete element modelling (DEM) paired with a single particle swelling model [1,2] and experimental liquid penetration depth data measured by a flow through cell [3] coupled with a commercial terahertz (THz) system (TeraPulse 4000, Teraview Ltd., UK).

KW - pharmaceutical tablet swelling

KW - discrete element modeling

KW - single particle model

M3 - Poster

SP - 33

EP - 33

T2 - CMAC Annual Open Day 2022

Y2 - 16 May 2022 through 18 May 2022

ER -

Modelling the swelling of pharmaceutical tablets from single particle understanding using DEM

Abstract

Conference

Keywords

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