Modelling of co-rotating twin-screw extruders in the pharmaceutical industry I: single component model

Pavol Rajniak, Maria Fuentes-Gari, Niall Mitchell, Muhammad Tariqul Islam, John Robertson, Sean K Bermingham

Research output: Contribution to conferenceAbstract

Abstract

Twin-screw extruders are being increasingly applied in the pharmaceutical industry for the manufacture of solid dispersions. In particular, Hot Melt Extrusion (HME) is a viable manufacturing alternative for poorly soluble drugs that are difficult to process. This is due to the high shear stress applied in the process, which enhances mixing of the base polymer with the dispersed API. Delivery systems that can be obtained using this technology include pellets, granules, sustained release tablets and implants. Experiments for HME are typically very labour-intensive, involving the use of highly viscous polymers, high pressures, and require proper cleaning between runs. Identifying the critical experiments to perform based on model simulations would thus be highly desirable. Single-component modelling of twin-screw extrusion processes could be beneficial in the following areas: identifying optimal screw configurations, tracking the degree of melting and when identifying the area within the extruder where the polymer becomes completely melted.

Conference

Conference2016 AIChE Annual Meeting
CountryUnited States
CityCA
Period13/11/1618/11/16
Internet address

Fingerprint

Drug Industry
Polymers
Freezing
Tablets
Technology
Pressure
Pharmaceutical Preparations

Keywords

  • pharmaceutical manufacturing
  • twin-screw extrusion
  • pharmaceutical industry

Cite this

Rajniak, P., Fuentes-Gari, M., Mitchell, N., Islam, M. T., Robertson, J., & Bermingham, S. K. (2016). Modelling of co-rotating twin-screw extruders in the pharmaceutical industry I: single component model. Abstract from 2016 AIChE Annual Meeting, CA, United States.
Rajniak, Pavol ; Fuentes-Gari, Maria ; Mitchell, Niall ; Islam, Muhammad Tariqul ; Robertson, John ; Bermingham, Sean K . / Modelling of co-rotating twin-screw extruders in the pharmaceutical industry I : single component model. Abstract from 2016 AIChE Annual Meeting, CA, United States.1 p.
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abstract = "Twin-screw extruders are being increasingly applied in the pharmaceutical industry for the manufacture of solid dispersions. In particular, Hot Melt Extrusion (HME) is a viable manufacturing alternative for poorly soluble drugs that are difficult to process. This is due to the high shear stress applied in the process, which enhances mixing of the base polymer with the dispersed API. Delivery systems that can be obtained using this technology include pellets, granules, sustained release tablets and implants. Experiments for HME are typically very labour-intensive, involving the use of highly viscous polymers, high pressures, and require proper cleaning between runs. Identifying the critical experiments to perform based on model simulations would thus be highly desirable. Single-component modelling of twin-screw extrusion processes could be beneficial in the following areas: identifying optimal screw configurations, tracking the degree of melting and when identifying the area within the extruder where the polymer becomes completely melted.",
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Rajniak, P, Fuentes-Gari, M, Mitchell, N, Islam, MT, Robertson, J & Bermingham, SK 2016, 'Modelling of co-rotating twin-screw extruders in the pharmaceutical industry I: single component model' 2016 AIChE Annual Meeting, CA, United States, 13/11/16 - 18/11/16, .

Modelling of co-rotating twin-screw extruders in the pharmaceutical industry I : single component model. / Rajniak, Pavol; Fuentes-Gari, Maria; Mitchell, Niall; Islam, Muhammad Tariqul; Robertson, John; Bermingham, Sean K .

2016. Abstract from 2016 AIChE Annual Meeting, CA, United States.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Modelling of co-rotating twin-screw extruders in the pharmaceutical industry I

T2 - single component model

AU - Rajniak, Pavol

AU - Fuentes-Gari, Maria

AU - Mitchell, Niall

AU - Islam, Muhammad Tariqul

AU - Robertson, John

AU - Bermingham, Sean K

PY - 2016/11/13

Y1 - 2016/11/13

N2 - Twin-screw extruders are being increasingly applied in the pharmaceutical industry for the manufacture of solid dispersions. In particular, Hot Melt Extrusion (HME) is a viable manufacturing alternative for poorly soluble drugs that are difficult to process. This is due to the high shear stress applied in the process, which enhances mixing of the base polymer with the dispersed API. Delivery systems that can be obtained using this technology include pellets, granules, sustained release tablets and implants. Experiments for HME are typically very labour-intensive, involving the use of highly viscous polymers, high pressures, and require proper cleaning between runs. Identifying the critical experiments to perform based on model simulations would thus be highly desirable. Single-component modelling of twin-screw extrusion processes could be beneficial in the following areas: identifying optimal screw configurations, tracking the degree of melting and when identifying the area within the extruder where the polymer becomes completely melted.

AB - Twin-screw extruders are being increasingly applied in the pharmaceutical industry for the manufacture of solid dispersions. In particular, Hot Melt Extrusion (HME) is a viable manufacturing alternative for poorly soluble drugs that are difficult to process. This is due to the high shear stress applied in the process, which enhances mixing of the base polymer with the dispersed API. Delivery systems that can be obtained using this technology include pellets, granules, sustained release tablets and implants. Experiments for HME are typically very labour-intensive, involving the use of highly viscous polymers, high pressures, and require proper cleaning between runs. Identifying the critical experiments to perform based on model simulations would thus be highly desirable. Single-component modelling of twin-screw extrusion processes could be beneficial in the following areas: identifying optimal screw configurations, tracking the degree of melting and when identifying the area within the extruder where the polymer becomes completely melted.

KW - pharmaceutical manufacturing

KW - twin-screw extrusion

KW - pharmaceutical industry

UR - https://aiche.confex.com/aiche/2016/webprogram/Paper461578.html

UR - http://www3.aiche.org/proceedings/Abstract.aspx?PaperID=461578

M3 - Abstract

ER -

Rajniak P, Fuentes-Gari M, Mitchell N, Islam MT, Robertson J, Bermingham SK. Modelling of co-rotating twin-screw extruders in the pharmaceutical industry I: single component model. 2016. Abstract from 2016 AIChE Annual Meeting, CA, United States.