TY - JOUR
T1 - Modelling drug-eluting stents
AU - McGinty, Sean
AU - Mckee, Sean
AU - Wadsworth, Roger
AU - McCormick, Christopher
PY - 2010/4/22
Y1 - 2010/4/22
N2 - In this study, we consider a family of mathematical models to describe the elution of drug from polymer-coated stents into the arterial wall. Our models include the polymer layer, the media, the adventitia, a possible topcoat polymer layer and atherosclerotic plaque. We investigate the relative importance of transmural convection, diffusion and drug-dependent parameters in drug delivery and deposition. Furthermore, we investigate how the release rate from the stent can be altered and examine the resulting effect on cellular drug concentrations.
AB - In this study, we consider a family of mathematical models to describe the elution of drug from polymer-coated stents into the arterial wall. Our models include the polymer layer, the media, the adventitia, a possible topcoat polymer layer and atherosclerotic plaque. We investigate the relative importance of transmural convection, diffusion and drug-dependent parameters in drug delivery and deposition. Furthermore, we investigate how the release rate from the stent can be altered and examine the resulting effect on cellular drug concentrations.
KW - drug-eluting stents
KW - Laplace transforms
KW - sensitivity analysis
UR - http://www.scopus.com/inward/record.url?scp=79952593018&partnerID=8YFLogxK
UR - http://imammb.oxfordjournals.org/content/28/1/1.short?rss=1
U2 - 10.1093/imammb/dqq003
DO - 10.1093/imammb/dqq003
M3 - Article
SN - 0265-0746
VL - 28
SP - 1
EP - 29
JO - Mathematical Medicine and Biology
JF - Mathematical Medicine and Biology
IS - 1
ER -