Modelling drug-eluting stents

Sean McGinty, Sean Mckee, Roger Wadsworth, Christopher McCormick

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

In this study, we consider a family of mathematical models to describe the elution of drug from polymer-coated stents into the arterial wall. Our models include the polymer layer, the media, the adventitia, a possible topcoat polymer layer and atherosclerotic plaque. We investigate the relative importance of transmural convection, diffusion and drug-dependent parameters in drug delivery and deposition. Furthermore, we investigate how the release rate from the stent can be altered and examine the resulting effect on cellular drug concentrations.
LanguageEnglish
Pages1-29
Number of pages30
JournalMathematical Medicine and Biology
Volume28
Issue number1
DOIs
Publication statusPublished - 22 Apr 2010

Fingerprint

Stent
Drug-Eluting Stents
Stents
Drugs
Polymers
drug
drugs
polymers
polymer
Modeling
Pharmaceutical Preparations
modeling
Adventitia
Convection
Drug Delivery
Convection-diffusion
Atherosclerotic Plaques
Drug delivery
Theoretical Models
Mathematical Model

Keywords

  • drug-eluting stents
  • Laplace transforms
  • sensitivity analysis

Cite this

McGinty, Sean ; Mckee, Sean ; Wadsworth, Roger ; McCormick, Christopher. / Modelling drug-eluting stents. In: Mathematical Medicine and Biology. 2010 ; Vol. 28, No. 1. pp. 1-29.
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Modelling drug-eluting stents. / McGinty, Sean; Mckee, Sean; Wadsworth, Roger; McCormick, Christopher.

In: Mathematical Medicine and Biology, Vol. 28, No. 1, 22.04.2010, p. 1-29.

Research output: Contribution to journalArticle

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