Modelling drug-eluting stents

Sean McGinty, Sean Mckee, Roger Wadsworth, Christopher McCormick

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

In this study, we consider a family of mathematical models to describe the elution of drug from polymer-coated stents into the arterial wall. Our models include the polymer layer, the media, the adventitia, a possible topcoat polymer layer and atherosclerotic plaque. We investigate the relative importance of transmural convection, diffusion and drug-dependent parameters in drug delivery and deposition. Furthermore, we investigate how the release rate from the stent can be altered and examine the resulting effect on cellular drug concentrations.
Original languageEnglish
Pages (from-to)1-29
Number of pages30
JournalMathematical Medicine and Biology
Volume28
Issue number1
DOIs
Publication statusPublished - 22 Apr 2010

Keywords

  • drug-eluting stents
  • Laplace transforms
  • sensitivity analysis

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