Modelling and simulation of the hydrodynamics and mixing profiles in the human proximal colon using Discrete Multiphysics

M. Schütt, K. Stamatopoulos, M. J.H. Simmons, H. K. Batchelor, A. Alexiadis

Research output: Contribution to journalArticle

Abstract

The proximal part of the colon offers opportunities to prolong the absorption window following oral administration of a drug. In this work, we used computer simulations to understand how the hydrodynamics in the proximal colon might affect the release from dosage forms designed to target the colon. For this purpose, we developed and compared three different models: a completely-filled colon, a partially-filled colon and a partially-filled colon with a gaseous phase present (gas-liquid model). The highest velocities of the liquid were found in the completely-filled model, which also shows the best mixing profile, defined by the distribution of tracking particles over time. No significant differences with regard to the mixing and velocity profiles were found between the partially-filled model and the gas-liquid model. The fastest transit time of an undissolved tablet was found in the completely-filled model. The velocities of the liquid in the gas-liquid model are slightly higher along the colon than in the partially-filled model. The filling level has an impact on the exsisting shear forces and shear rates, which are decisive factors in the development of new drugs and formulations.

Original languageEnglish
Article number103819
JournalComputers in Biology and Medicine
Volume121
Early online date18 May 2020
DOIs
Publication statusPublished - 30 Jun 2020

Keywords

  • colon
  • drug delivery
  • fluid dynamics
  • fluid-structure interactions
  • large intestine
  • mathematical modelling
  • peristalsis
  • proximal colon
  • Smoothed Particle Hydrodynamics (SPH)

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    Schütt, M., Stamatopoulos, K., Simmons, M. J. H., Batchelor, H. K., & Alexiadis, A. (2020). Modelling and simulation of the hydrodynamics and mixing profiles in the human proximal colon using Discrete Multiphysics. Computers in Biology and Medicine, 121, [103819]. https://doi.org/10.1016/j.compbiomed.2020.103819