Model development and optimal experimental design of a kinetically controlled synthesis system

Research output: Contribution to conferenceProceeding

6 Citations (Scopus)

Abstract

A mathematical model has been developed for an enzymatic process with kinetically
controlled synthesis. Model reduction and detailed system analysis have been undertaken to
examine the main properties of this enzyme reaction system. Optimal experimental design
(OED) is developed to obtain the experimental conditions that will generate the most informative measurement data for parameter estimation. Both single-input and multiple-inputs optimisation strategies have been investigated to determine the best intensity levels of control inputs. The results demonstrate that parameter estimation quality can be improved through proper model-based experimental design.
Original languageEnglish
Pages332-337
Number of pages6
Publication statusPublished - 16 Dec 2013
EventInternational Symposium on Computer Applications in Biotechnology (CAB2013) - Mumbai, India
Duration: 16 Dec 201318 Dec 2013

Conference

ConferenceInternational Symposium on Computer Applications in Biotechnology (CAB2013)
CountryIndia
CityMumbai
Period16/12/1318/12/13

Keywords

  • model development
  • optimal experiment design
  • multiple objective optimization
  • least squares parameter estimation
  • enzyme reaction networks

Fingerprint Dive into the research topics of 'Model development and optimal experimental design of a kinetically controlled synthesis system'. Together they form a unique fingerprint.

  • Cite this

    Yue, H., Halling, P., & Yu, H. (2013). Model development and optimal experimental design of a kinetically controlled synthesis system. 332-337. International Symposium on Computer Applications in Biotechnology (CAB2013), Mumbai, India.