MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

Daniela Kalafatovic, Max Nobis, Nadeem Javid, Pim W. J. M. Frederix, Kurt I. Anderson, Brian R. Saunders, Rein V. Ulijn

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Abstract

Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.

Original languageEnglish
Pages (from-to)246-249
Number of pages4
JournalBiomaterials Science
Volume3
Issue number2
Early online date28 Oct 2014
DOIs
Publication statusPublished - 20 Feb 2015

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Keywords

  • hydrophobic anticancer drugs
  • micellar aggregates
  • doxorubicin

Cite this

Kalafatovic, D., Nobis, M., Javid, N., Frederix, P. W. J. M., Anderson, K. I., Saunders, B. R., & Ulijn, R. V. (2015). MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin. Biomaterials Science, 3(2), 246-249. https://doi.org/10.1039/c4bm00297k