Abstract
Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.
Original language | English |
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Pages (from-to) | 246-249 |
Number of pages | 4 |
Journal | Biomaterials Science |
Volume | 3 |
Issue number | 2 |
Early online date | 28 Oct 2014 |
DOIs | |
Publication status | Published - 20 Feb 2015 |
Keywords
- hydrophobic anticancer drugs
- micellar aggregates
- doxorubicin