MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

Daniela Kalafatovic, Max Nobis, Nadeem Javid, Pim W. J. M. Frederix, Kurt I. Anderson, Brian R. Saunders, Rein V. Ulijn

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.

LanguageEnglish
Pages246-249
Number of pages4
JournalBiomaterials Science
Volume3
Issue number2
Early online date28 Oct 2014
DOIs
Publication statusPublished - 20 Feb 2015

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Nanofibers
Micelles
Matrix Metalloproteinases
Doxorubicin
Peptides
Amphiphiles
Fibers
Enzymes
Pharmaceutical Preparations

Keywords

  • hydrophobic anticancer drugs
  • micellar aggregates
  • doxorubicin

Cite this

Kalafatovic, D., Nobis, M., Javid, N., Frederix, P. W. J. M., Anderson, K. I., Saunders, B. R., & Ulijn, R. V. (2015). MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin. Biomaterials Science, 3(2), 246-249. https://doi.org/10.1039/c4bm00297k
Kalafatovic, Daniela ; Nobis, Max ; Javid, Nadeem ; Frederix, Pim W. J. M. ; Anderson, Kurt I. ; Saunders, Brian R. ; Ulijn, Rein V. / MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin. In: Biomaterials Science. 2015 ; Vol. 3, No. 2. pp. 246-249.
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Kalafatovic, D, Nobis, M, Javid, N, Frederix, PWJM, Anderson, KI, Saunders, BR & Ulijn, RV 2015, 'MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin' Biomaterials Science, vol. 3, no. 2, pp. 246-249. https://doi.org/10.1039/c4bm00297k

MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin. / Kalafatovic, Daniela; Nobis, Max; Javid, Nadeem; Frederix, Pim W. J. M.; Anderson, Kurt I.; Saunders, Brian R.; Ulijn, Rein V.

In: Biomaterials Science, Vol. 3, No. 2, 20.02.2015, p. 246-249.

Research output: Contribution to journalArticle

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Kalafatovic D, Nobis M, Javid N, Frederix PWJM, Anderson KI, Saunders BR et al. MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin. Biomaterials Science. 2015 Feb 20;3(2):246-249. https://doi.org/10.1039/c4bm00297k