MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

Daniela Kalafatovic; Max Nobis; Nadeem Javid; Pim W. J. M. Frederix; Kurt I. Anderson; Brian R. Saunders; Rein V. Ulijn

doi:10.1039/c4bm00297k

MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

Daniela Kalafatovic, Max Nobis, Nadeem Javid, Pim W. J. M. Frederix, Kurt I. Anderson, Brian R. Saunders, Rein V. Ulijn

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Abstract

Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.

Original language	English
Pages (from-to)	246-249
Number of pages	4
Journal	Biomaterials Science
Volume	3
Issue number	2
Early online date	28 Oct 2014
DOIs	https://doi.org/10.1039/c4bm00297k
Publication status	Published - 20 Feb 2015

Keywords

hydrophobic anticancer drugs
micellar aggregates
doxorubicin

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10.1039/c4bm00297k

Kalafatovic-etal-BS-2015-MMP-9-triggered-micelle-to-fibre-transitions-for-slow-releaseFinal published version, 823 KBLicence: CC BY 4.0

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abstract = "Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.",

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AU - Frederix, Pim W. J. M.

AU - Anderson, Kurt I.

AU - Saunders, Brian R.

AU - Ulijn, Rein V.

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AB - Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.

KW - hydrophobic anticancer drugs

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KW - doxorubicin

U2 - 10.1039/c4bm00297k

DO - 10.1039/c4bm00297k

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JO - Biomaterials Science

JF - Biomaterials Science

SN - 2047-4830

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MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

Abstract

Keywords

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