MKP-2: out of the DUSP-bin and back into the limelight

A. Lawan, E. Torrance, S. Al-Harthi, M. Shweash, S. Alnasser, T. Neamatallah, J. Schroeder, R. Plevin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The MKPs (mitogen-activated protein kinase phosphatases) are a family of at least ten DUSPs (dual-specificity phosphatases) which function to terminate the activity of the MAPKs (mitogen-activated protein kinases). Several members have already been demonstrated to have distinct roles in immune function, cancer, fetal development and metabolic disorders. One DUSP of renewed interest is the inducible nuclear phosphatase MKP-2, which dephosphorylates both ERK (extracellular-signal-regulated kinase) and JNK (c-Jun N-terminal kinase) in vitro. Recently, the understanding of MKP-2 function has been advanced due to the development of mouse knockout models, which has resulted in the discovery of novel roles for MKP-2 in the regulation of sepsis, infection and cell-cycle progression that are distinct from those of other DUSPs. However, many functions for MKP-2 still await to be characterized
Original languageEnglish
Pages (from-to)235-239
Number of pages5
JournalBiochemical Society Transactions
Volume40
Early online date19 Jan 2012
DOIs
Publication statusPublished - 2012

Keywords

  • innate immune-responses
  • activated protein-kinase
  • proliferation
  • mitogen-activated protein kinase phosphatase 2 (MKP-2)
  • immunity
  • phosphatase
  • dual-specificity phosphatase (DUSP)
  • mitogen-activated protein kinase (MAPK)
  • cancer
  • DUSP-bin
  • limelight
  • mkp-2

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