Mitochondrial organization and Ca2+ uptake

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26 Citations (Scopus)

Abstract

Mitochondria may function as multiple separate organelles or as a single electrically coupled continuum to modulate changes in [Ca2+]c (cytoplasmic Ca2+ concentration) in various cell types. Mitochondria may also be tethered to the internal Ca2+ store or plasma membrane in particular parts of cells to facilitate the organelles modulation of local and global [Ca2+]c increases. Differences in the organization and positioning contributes significantly to the at times apparently contradictory reports on the way mitochondria modulate [Ca2+]c signals. In the present paper, we review the organization of mitochondria and the organelles role in Ca2+ signalling.
Original languageEnglish
Pages (from-to)158-167
Number of pages10
JournalBiochemical Society Transactions
Volume40
Issue number1
DOIs
Publication statusPublished - 2012

Keywords

  • cell types
  • Mitochondria
  • Ca2+

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