Minor groove binders: some recent research in drug development

Abedawn I. Khalaf

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Abstract

The role of the naturally occurring polyamides distamycin and netropsin as antibacterial agents is described. Also, the importance of the modifications to the lipophilic and hydrophobic moieties is discussed. It has also been shown that these DNA minor groove binding compds. can be used to treat other diseases such as sleeping sickness when the right modifications have been employed. Examples of the synthetic strategy of these polypyrroles are also highlighted in this review.
Original languageEnglish
Pages (from-to)53-63
Number of pages11
JournalCurrent Trends in Medicinal Chemistry
Volume6
Publication statusPublished - 2009

Keywords

  • polyamides
  • distamycin
  • netropsin

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