Minor groove binders: some recent research in drug development

Abedawn I. Khalaf

Research output: Contribution to journalArticle

Abstract

The role of the naturally occurring polyamides distamycin and netropsin as antibacterial agents is described. Also, the importance of the modifications to the lipophilic and hydrophobic moieties is discussed. It has also been shown that these DNA minor groove binding compds. can be used to treat other diseases such as sleeping sickness when the right modifications have been employed. Examples of the synthetic strategy of these polypyrroles are also highlighted in this review.
LanguageEnglish
Pages53-63
Number of pages11
JournalCurrent Trends in Medicinal Chemistry
Volume6
Publication statusPublished - 2009

Fingerprint

Netropsin
Nylons
Binders
Anti-Bacterial Agents
DNA
Pharmaceutical Preparations
stallimycin
polypyrrole

Keywords

  • polyamides
  • distamycin
  • netropsin

Cite this

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abstract = "The role of the naturally occurring polyamides distamycin and netropsin as antibacterial agents is described. Also, the importance of the modifications to the lipophilic and hydrophobic moieties is discussed. It has also been shown that these DNA minor groove binding compds. can be used to treat other diseases such as sleeping sickness when the right modifications have been employed. Examples of the synthetic strategy of these polypyrroles are also highlighted in this review.",
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Minor groove binders: some recent research in drug development. / Khalaf, Abedawn I.

In: Current Trends in Medicinal Chemistry, Vol. 6, 2009, p. 53-63.

Research output: Contribution to journalArticle

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