Minor groove binders 1998-2004

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Several classes of compounds, including heterocyclic polyamides, aryl benzimidazoles, pyrrolobenzodiazepines, amidino arylfurans and benzofurans, have been found to bind to the minor groove of DNA with sequence selectivity and potential therapeutic consequences. Many such compounds are synthetic analogues of natural products such as distamycin, netropsin, CC-1065, duocarmycin and anthramycin. Biological activity has been demonstrated in antibacterial, antifungal, antiviral and anticancer applications, and several compounds are in clinical trials. This review covers patents since 1998 and reviews the structures, mechanisms and biological activity of minor groove binders in the context of the current scientific understanding described in the journal literature.
Original languageEnglish
Pages (from-to)1693-1724
Number of pages31
JournalExpert Opinion on Therapeutic Patents
Issue number12
Publication statusPublished - 1 Dec 2004


  • antibacterial agent
  • antifungal agent
  • antiviral agent
  • aryl benzimidazole
  • cancer chemotherapy
  • DNA binding compound
  • heterocyclic polyamide
  • minor groove
  • natural product analogue
  • pyrrolobenzodiazepine


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