Abstract
| Language | English |
|---|---|
| Pages | 1693-1724 |
| Number of pages | 31 |
| Journal | Expert Opinion on Therapeutic Patents |
| Volume | 14 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 1 Dec 2004 |
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Keywords
- antibacterial agent
- antifungal agent
- antiviral agent
- aryl benzimidazole
- cancer chemotherapy
- DNA binding compound
- heterocyclic polyamide
- minor groove
- natural product analogue
- pyrrolobenzodiazepine
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Minor groove binders 1998-2004. / Suckling, C.J.
In: Expert Opinion on Therapeutic Patents, Vol. 14, No. 12, 01.12.2004, p. 1693-1724.Research output: Contribution to journal › Article
TY - JOUR
T1 - Minor groove binders 1998-2004
AU - Suckling, C.J.
PY - 2004/12/1
Y1 - 2004/12/1
N2 - Several classes of compounds, including heterocyclic polyamides, aryl benzimidazoles, pyrrolobenzodiazepines, amidino arylfurans and benzofurans, have been found to bind to the minor groove of DNA with sequence selectivity and potential therapeutic consequences. Many such compounds are synthetic analogues of natural products such as distamycin, netropsin, CC-1065, duocarmycin and anthramycin. Biological activity has been demonstrated in antibacterial, antifungal, antiviral and anticancer applications, and several compounds are in clinical trials. This review covers patents since 1998 and reviews the structures, mechanisms and biological activity of minor groove binders in the context of the current scientific understanding described in the journal literature.
AB - Several classes of compounds, including heterocyclic polyamides, aryl benzimidazoles, pyrrolobenzodiazepines, amidino arylfurans and benzofurans, have been found to bind to the minor groove of DNA with sequence selectivity and potential therapeutic consequences. Many such compounds are synthetic analogues of natural products such as distamycin, netropsin, CC-1065, duocarmycin and anthramycin. Biological activity has been demonstrated in antibacterial, antifungal, antiviral and anticancer applications, and several compounds are in clinical trials. This review covers patents since 1998 and reviews the structures, mechanisms and biological activity of minor groove binders in the context of the current scientific understanding described in the journal literature.
KW - antibacterial agent
KW - antifungal agent
KW - antiviral agent
KW - aryl benzimidazole
KW - cancer chemotherapy
KW - DNA binding compound
KW - heterocyclic polyamide
KW - minor groove
KW - natural product analogue
KW - pyrrolobenzodiazepine
UR - http://dx.doi.org/10.1517/13543776.14.12.1693
U2 - 10.1517/13543776.14.12.1693
DO - 10.1517/13543776.14.12.1693
M3 - Article
VL - 14
SP - 1693
EP - 1724
JO - Expert Opinion on Therapeutic Patents
T2 - Expert Opinion on Therapeutic Patents
JF - Expert Opinion on Therapeutic Patents
SN - 1354-3776
IS - 12
ER -