Abstract
Cucurbit[n]urils (CB[n]; n = 5, 6, 7, 8 or 10) are a family of macrocycles made from the acid-catalyzed condensation of glycoluril and formaldehyde. The synthesis of CB[n] using microwave radiation has been examined and the effect of acid type, reaction time and temperature on the distribution of products has been determined. Synthesis in HCl yields CB[5], CB[6], CB[7] and CB[8] in 10 min and is most efficient at 160°C. Synthesis in H2SO4 yields mostly CB[6] in 3 min and is most efficient at 160°C. Microwave synthesis provides an efficient and cost-effective method for the large-scale production of CB[n] for a range of applications, particularly drug delivery.
Original language | English |
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Pages (from-to) | 231-236 |
Number of pages | 5 |
Journal | Future Medicinal Chemistry |
Volume | 2 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2010 |
Keywords
- cucurbit
- macrocycles
- acid-catalyzed condensation
- glycoluril
- formaldehyde
- microwave radiation
- microwave synthesis