Microrheology with optical tweezers

Alison Yao, Manlio Tassieri, Miles Padgett, Jonathan Cooper

Research output: Contribution to journalLiterature review

90 Citations (Scopus)


Microrheology is the study of the flow of materials over small scales. It is of particular interest to those involved with investigations of fluid properties within Lab-on-a-Chip structures or within other micron-scale environments. The article briefly reviews existing active and passive methods used in the study of fluids. It then explores in greater detail the use of optical tweezers as an emerging method to investigate rheological phenomena, including, for example, viscosity and viscoelasticity, as well as the related topic of flow. The article also describes, briefly, potential future applications of this topic, in the fields of biological measurement, in general, and Lab-on-a-Chip, in particular.

Original languageEnglish
Pages (from-to)2568-2575
Number of pages8
JournalLab on a Chip
Issue number17
Early online date15 Jun 2009
Publication statusPublished - 2009



  • computer-generated holograms
  • diffusing-wave spectroscopy
  • radiation pressure
  • biological cells
  • force microscopy
  • angular-momentum
  • local viscosity
  • complex fluids
  • living cells
  • particles

Cite this

Yao, A., Tassieri, M., Padgett, M., & Cooper, J. (2009). Microrheology with optical tweezers. Lab on a Chip, 9(17), 2568-2575. https://doi.org/10.1039/b907992k