Micromachined scaffolds as primers for cartilage growth

Research output: Contribution to journalArticle

Abstract

Research on the growth and monitoring of cartilage cells in a controlled microstructured environment is important because of the consideration of how the microenvironment affects the cells involved in cartilage regeneration has been neglected to date. An experimental realisation has been demonstrated of biocompatible microstructured surfaces of controlled topography, which have been formed in biocompatible polyimide (Kapton) and in synthetic bioresorbable, epsilon-polycaprolactone (PCL). Bovine cartilage cell growth has been achieved in vitro on the microstructured surfaces and the retention of chondrocytic morphology has been investigated. The results demonstrate that PCL and Kapton microgrooved surfaces can act as primers for cartilage regeneration and repair in vitro or potentially in vivo, by retaining chondrocytic phenotype and enhancing cartilage formation.
Original languageEnglish
Pages (from-to)66-70
Number of pages4
JournalMicro and Nano Letters
Volume1
Issue number2
DOIs
Publication statusPublished - 2006

Keywords

  • bioengineering
  • microstructured environment
  • cartilage
  • micro-biology

Fingerprint Dive into the research topics of 'Micromachined scaffolds as primers for cartilage growth'. Together they form a unique fingerprint.

  • Cite this