Micromachined scaffolds as primers for cartilage growth

Research output: Contribution to journalArticle

Abstract

Research on the growth and monitoring of cartilage cells in a controlled microstructured environment is important because of the consideration of how the microenvironment affects the cells involved in cartilage regeneration has been neglected to date. An experimental realisation has been demonstrated of biocompatible microstructured surfaces of controlled topography, which have been formed in biocompatible polyimide (Kapton) and in synthetic bioresorbable, epsilon-polycaprolactone (PCL). Bovine cartilage cell growth has been achieved in vitro on the microstructured surfaces and the retention of chondrocytic morphology has been investigated. The results demonstrate that PCL and Kapton microgrooved surfaces can act as primers for cartilage regeneration and repair in vitro or potentially in vivo, by retaining chondrocytic phenotype and enhancing cartilage formation.
LanguageEnglish
Pages66-70
Number of pages4
JournalMicro and Nano Letters
Volume1
Issue number2
DOIs
Publication statusPublished - 2006

Fingerprint

primers
cartilage
Cartilage
Scaffolds
Kapton (trademark)
Polycaprolactone
regeneration
phenotype
Cell growth
retaining
cells
polyimides
Polyimides
Topography
topography
Repair
Monitoring

Keywords

  • bioengineering
  • microstructured environment
  • cartilage
  • micro-biology

Cite this

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Micromachined scaffolds as primers for cartilage growth. / Angeli, F.; Connolly, P.; Uttamchandani, D.G.

In: Micro and Nano Letters, Vol. 1, No. 2, 2006, p. 66-70.

Research output: Contribution to journalArticle

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T1 - Micromachined scaffolds as primers for cartilage growth

AU - Angeli, F.

AU - Connolly, P.

AU - Uttamchandani, D.G.

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AB - Research on the growth and monitoring of cartilage cells in a controlled microstructured environment is important because of the consideration of how the microenvironment affects the cells involved in cartilage regeneration has been neglected to date. An experimental realisation has been demonstrated of biocompatible microstructured surfaces of controlled topography, which have been formed in biocompatible polyimide (Kapton) and in synthetic bioresorbable, epsilon-polycaprolactone (PCL). Bovine cartilage cell growth has been achieved in vitro on the microstructured surfaces and the retention of chondrocytic morphology has been investigated. The results demonstrate that PCL and Kapton microgrooved surfaces can act as primers for cartilage regeneration and repair in vitro or potentially in vivo, by retaining chondrocytic phenotype and enhancing cartilage formation.

KW - bioengineering

KW - microstructured environment

KW - cartilage

KW - micro-biology

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