Micromachined glass apertures for artificial lipid bilayer formation in a microfluidic system

Mairi E. Sandison, Michele Zagnoni, Mustafa Abu-Hantash, Hywel Morgan

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The use of spark assisted chemical engraving (SACE) to produce glass apertures that are suitable for the formation of artificial bilayer lipid membranes is described. Prior to use, the glass apertures were rendered hydrophobic by a silanization process and were then incorporated into a simple microfluidic device. Successful bilayer lipid membrane (BLM) formation and the subsequent acquisition of single-channel recordings are demonstrated. Due to the simplicity and rapidity of the SACE process, these glass apertures could be easily integrated into an all-glass microfluidic system for BLM formation.
Original languageEnglish
Pages (from-to)S189-S196
Number of pages8
JournalJournal of Micromechanics and Microengineering
Volume17
Issue number7
DOIs
Publication statusPublished - 2 Jul 2007

Keywords

  • micromachining
  • glass apertures
  • artificial lipid bilayer
  • biological physics

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