Microfluidic system based on the digital holography microscope for analysis of motile sperm

G. Di Caprio*, G. Coppola, S. Grilli, P. Ferraro, R. Puglisi, D. Balduzzi, A. Galli

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

2 Citations (Scopus)

Abstract

Digital holography (DH) has been employed in the retrieval of three dimensional images of bull?s sperm heads. The system allows a three dimensional analysis of the sperm morphology by means of a Digital Holographic Microscope (DHM). Microscopic holography measurements are performed by projecting a magnified image of a microscopic hologram plane onto a CCD plane. This could constitute the basis of an alternative method for the zoothecnic industry aimed at the investigation of morphological features and the sorting of the motile sperm cells. Indeed, one of the main advantages of digital holography consists in its full non-invasivity and in the capability of investigating the shape of the sperm cells without altering their characteristics. In particular the proposed technique could be applied to investigate the frequency of aberrant spermatozoa. Until now, in fact, such industrial investigations have been mainly performed by means of specific painting probes: unfortunately this technique dramatically reduces the vitality of the sperm cells and can even cause chromosome aberration, making them useless for the zootechnical applications.

Original languageEnglish
Title of host publicationOptical Measurement Systems for Industrial Inspection VI
EditorsPeter H. Lehmann
Place of PublicationBellingham, Washington
Number of pages9
DOIs
Publication statusPublished - 17 Jun 2009
EventOptical Measurement Systems for Industrial Inspection VI - Munich, Germany
Duration: 15 Jun 200918 Jun 2009

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume7389
ISSN (Print)0277-786X

Conference

ConferenceOptical Measurement Systems for Industrial Inspection VI
Country/TerritoryGermany
CityMunich
Period15/06/0918/06/09

Keywords

  • digital holography microscope
  • in-vivo cell analysis
  • microfluidic
  • quantitative phase-contrast map

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