Microfactory – Blend – Compression - Performance test

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Abstract

Aims and objectives
- API’s with acicular habits are commonplace and present processing and handling challenges due to poor flow. This is traditionally addressed by wet granulation processes during formulation. Currently continuous direct compression (CDC) is gaining favour as a simplified formulation and dose formation process. However, poor flow properties limit CDC. This work aims to enable CDC by spherical agglomeration in the primary process and develop underpinning modelling approaches to allow formulations to be explored in-silico (i.e. digital twin)
- Here at CMAC an integrated crystalisation-spherical agglomeration-drying-blending-compression process is being developed (microfactory) to be used to parameterise and develop modelling tools on the g-formulate package
- This work presents some of the activities on the compression component to parameterise and develop a suitable model to enable the process to be explored (i.e. digital twin)
Original languageEnglish
Publication statusPublished - 25 Oct 2018
EventCMAC Annual Open Day -
Duration: 25 Oct 201826 Oct 2018

Conference

ConferenceCMAC Annual Open Day
Period25/10/1826/10/18

Keywords

  • microfactory
  • compression
  • gFormulate model

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