Microarray methods for protein biomarker detection

H.J. Lee, A.W. Wark, R.M. Corn

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

The application of protein biomarkers as an aid for the detection and treatment of diseases has been subject to intensified interest in recent years. The quantitative assaying of protein biomarkers in easily obtainable biological fluids such as serum and urine offers the opportunity to improve patient care via earlier and more accurate diagnoses in a convenient, non-invasive manner as well as providing a potential route towards more individually targeted treatment. Essential to achieving progress in biomarker technology is the ability to screen large numbers of proteins simultaneously in a single experiment with high sensitivity and selectivity. In this article, we highlight recent progress in the use of microarrays for high-throughput biomarker profiling and discuss some of the challenges associated with these efforts.
LanguageEnglish
Pages975-983
Number of pages8
JournalAnalyst
Volume133
Issue number8
DOIs
Publication statusPublished - 2008

Fingerprint

Protein Array Analysis
Biomarkers
Microarrays
biomarker
Proteins
protein
urine
aid
serum
Patient Care
Throughput
Urine
Technology
Fluids
fluid
method
detection
Therapeutics
Serum
experiment

Keywords

  • protein biomarkers

Cite this

Lee, H.J. ; Wark, A.W. ; Corn, R.M. / Microarray methods for protein biomarker detection. In: Analyst. 2008 ; Vol. 133, No. 8. pp. 975-983.
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Microarray methods for protein biomarker detection. / Lee, H.J.; Wark, A.W.; Corn, R.M.

In: Analyst, Vol. 133, No. 8, 2008, p. 975-983.

Research output: Contribution to journalArticle

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