Micro-LED arrays: a tool for two-dimensional neuron stimulation

V. Poher, N. Grossman, G.T. Kennedy, K. Nikolic, H.X. Zhang, Z. Gong, E.M. Drakakis, E. Gu, M.D. Dawson, P.M.W. French, P. Degenaar, M.A.A. Neil

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Stimulating neuron cells with light is an exciting new technology that is revolutionizing the neurosciences. To date, due to the optical complexity that is involved, photostimulation has only been achieved at a single site using high power light sources. Here we present a GaN based micro-light emitting diode (LED) array that can open the way to multi-site photostimulation of neuron cells. The device is a two-dimensional array of micrometre size LED emitters. Each emitter has the required wavelength, optical power and modulation bandwidth to trigger almost any photosensitizer and is individually addressable. We demonstrate micrometre resolution photoactivation of a caged fluorophore and photostimulation of sensitized living neuron cells. In addition, a complete system that combines the micro-LED array with multi-site electrophysiological recording based on microelectrode array technology and/or fluorescence imaging is presented.
Original languageEnglish
Pages (from-to)094014
Number of pages8
JournalJournal of Physics D: Applied Physics
Volume41
Issue number9
DOIs
Publication statusPublished - 4 Apr 2008

Keywords

  • micro-LED arrays
  • neuron stimulation
  • LED
  • neuron cells
  • neurosciences
  • photostimulation
  • optics

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