Micro-endoscope for in vivo widefield high spatial resolution fluorescent imaging

C. D. Saunter; S. Semprini; C. Buckley; J. Mullins; J. M. Girkin

doi:10.1364/BOE.3.001274

Micro-endoscope for in vivo widefield high spatial resolution fluorescent imaging

C. D. Saunter, S. Semprini, C. Buckley, J. Mullins, J. M. Girkin

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

In this paper we report the design, testing and use of a scannerless probe specifically for minimally invasive imaging of deep tissue in vivo with an epi-fluorescence modality. The probe images a 500 μm diameter field of view through a 710 μm outer diameter probe with a maximum tissue penetration depth of 15 mm specifically configured for eGFP imaging. Example results are given from imaging the pituitary gland of rats and zebrafish hearts with lateral resolution of 2.5 μm.

Original language	English
Pages (from-to)	1274-1278
Number of pages	5
Journal	Biomedical Optics Express
Volume	3
Issue number	6
DOIs	https://doi.org/10.1364/BOE.3.001274
Publication status	Published - 4 May 2012

Keywords

fluorescence microscopy
endoscopic imaging
scannerless probe

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10.1364/BOE.3.001274

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abstract = "In this paper we report the design, testing and use of a scannerless probe specifically for minimally invasive imaging of deep tissue in vivo with an epi-fluorescence modality. The probe images a 500 μm diameter field of view through a 710 μm outer diameter probe with a maximum tissue penetration depth of 15 mm specifically configured for eGFP imaging. Example results are given from imaging the pituitary gland of rats and zebrafish hearts with lateral resolution of 2.5 μm.",

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AU - Semprini, S.

AU - Buckley, C.

AU - Mullins, J.

AU - Girkin, J. M.

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KW - fluorescence microscopy

KW - endoscopic imaging

KW - scannerless probe

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DO - 10.1364/BOE.3.001274

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JO - Biomedical Optics Express

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Micro-endoscope for in vivo widefield high spatial resolution fluorescent imaging

Abstract

Keywords

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