Methylphenidate restores visual memory, but not working memory function in attention deficit-hyperkinetic disorder

Sinéad M. Rhodes, David Coghill, Keith M. Matthews

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Dysfunction of executive neuropsychological performance, mediated by the prefrontal cortex, has been the central focus of recent attention deficit/ hyperkinetic disorder (AD-HKD) research. The role of other potential neuropsychological 'risk factors', such as recognition memory, remains understudied. Further, the impact of methylphenidate (MPH) on key neuropsychological processes in AD-HKD remains poorly understood. To compare the performance of boys with AD-HKD on a spatial working memory (SWM) task and on two non-working memory tasks [a simultaneous and delayed matching-to-sample task (DMtS) and a patternrecognition task] with that of healthy boys, and to investigate the impact of acute and chronic MPH on performance of these tasks. Methods: Baseline performance of 75 stimulant-naive boys with AD-HKD was compared with that of 70 healthy boys. The AD-HKD boys were then re-tested following the administration of acute and chronic challenges with MPH (0.3 mg/kg and 0.6 mg/kg) under randomised double-blind placebo controlled conditions. Results: Compared with healthy boys, the AD-HKD boys demonstrated performance deficits on all neuropsychological tasks. A single dose of MPH restored performance on the DMtS task but had no impact on the SWM or pattern-recognition tasks. Chronic MPH administration did not alter performance on the SWM task but did improve performance on both the pattern-recognition and DMtS tasks. However, the acute restorative effect of MPH on DMtS diminished with repeated administration. Our results suggest that current conceptualisations of the neuropsychological basis of AD-HKD and the proposed therapeutic mechanisms of MPH require broadening.
LanguageEnglish
Pages319-330
Number of pages11
JournalPsychopharmacology
Volume175
DOIs
Publication statusPublished - 8 May 2004

Fingerprint

Methylphenidate
Attention Deficit Disorder with Hyperactivity
Short-Term Memory
Prefrontal Cortex
Placebos
Research

Keywords

  • ADHD
  • methylphenidate
  • CANTAB
  • delayed matching to sample
  • visual memory
  • working memory
  • tolerance

Cite this

Rhodes, Sinéad M. ; Coghill, David ; Matthews, Keith M. / Methylphenidate restores visual memory, but not working memory function in attention deficit-hyperkinetic disorder. In: Psychopharmacology. 2004 ; Vol. 175. pp. 319-330.
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Methylphenidate restores visual memory, but not working memory function in attention deficit-hyperkinetic disorder. / Rhodes, Sinéad M.; Coghill, David; Matthews, Keith M.

In: Psychopharmacology, Vol. 175, 08.05.2004, p. 319-330.

Research output: Contribution to journalArticle

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