Methods for nanoparticle labeling of ricin and effect on toxicity

Alastair Wark, Jun Yu, C. D. Lindsay, Paola Nativo, Duncan Graham

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

54 Downloads (Pure)


The unique optical properties associated with nanostructured materials that support the excitation of surface plasmons offer many new opportunities for the enhanced optical investigation of biological materials that pose a security threat. In particular, ricin is considered a significant bioterrorism risk due to its high toxicity combined with its ready availability as a byproduct in castor oil production. Therefore, the development of optical techniques capable of rapid on-site toxin detection with high molecular specificity and sensitivity continues to be of significant importance. Furthermore, understanding of the ricin cell entry and intracellular pathways remains poor due to a lack of suitable bioanalytical
techniques. Initial work aimed at simultaneously tackling both these issues is described where different approaches for the nanoparticle labeling of ricin are investigated along with changes in ricin toxicity associated with the labeling
Original languageEnglish
Title of host publicationMethods for nanoparticle labeling of ricin and effect on toxicity
Publication statusPublished - Sep 2009


Dive into the research topics of 'Methods for nanoparticle labeling of ricin and effect on toxicity'. Together they form a unique fingerprint.

Cite this