Metallosomes for biomedical applications by mixing molybdenum carbonyl metallosurfactants and phospholipids

M. Marín-García, N. Benseny-Cases, M. Camacho, Y. Perrie, J. Suades, R. Barnadas-Rodríguez

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

New supramolecular systems have been prepared by mixing molybdenum organometallic metallosurfactants M(CO)5L and M(CO)4L2 {L = Ph2P(CH2)6SO3Na} with the phospholipid phosphatidylcholine. The analysis of the resulting supramolecular structures using dynamic light scattering and cryo-transmission electron microscopy has shown the formation of different aggregates depending on the metallosurfactant/phospholipid ratio, as well as a significantly different behaviour between the two studied metallosurfactants. Mixed vesicles, with properties very similar to liposomes, can be obtained with both compounds, and are called metallosomes. The formation of the mixed aggregates has also been studied by microfluidics using MeOH and EtOH as organic solvents, and it has been observed that the size of the aggregates is strongly dependent on the organic solvent used. In order to analyse the viability of these mixed systems as CO Releasing Molecules (CORMs) for biomedical applications, the CO release was studied by FT-IR spectroscopy, showing that they behave as photo-CORMs with visible and ultraviolet light. Toxicity studies of the different mixed aggregate systems have shown that metallosomes exhibit a very low toxicity, similar to liposomes that do not contain metallosurfactants, which is well below the results observed for pure metallosurfactants. Micro-FTIR microscopy using synchrotron radiation has shown the presence of metallosurfactants in cells. The results of this study show the influence of the length of the hydrocarbon chain on the properties of these mixed systems, compared with previously reported data.

LanguageEnglish
Number of pages11
JournalDalton Transactions
Early online date28 Jun 2018
DOIs
Publication statusE-pub ahead of print - 28 Jun 2018

Fingerprint

Molybdenum
Carbon Monoxide
Phospholipids
Liposomes
Organic solvents
Toxicity
Molecules
Organometallics
Dynamic light scattering
Hydrocarbons
Synchrotron radiation
Phosphatidylcholines
Microfluidics
Infrared spectroscopy
Microscopic examination
Transmission electron microscopy

Keywords

  • metallosurfactants
  • phospholipids
  • dynamic light scattering

Cite this

Marín-García, M. ; Benseny-Cases, N. ; Camacho, M. ; Perrie, Y. ; Suades, J. ; Barnadas-Rodríguez, R. / Metallosomes for biomedical applications by mixing molybdenum carbonyl metallosurfactants and phospholipids. In: Dalton Transactions. 2018.
@article{6ddc884c30a74da9aa3e74e9f9860f3f,
title = "Metallosomes for biomedical applications by mixing molybdenum carbonyl metallosurfactants and phospholipids",
abstract = "New supramolecular systems have been prepared by mixing molybdenum organometallic metallosurfactants M(CO)5L and M(CO)4L2 {L = Ph2P(CH2)6SO3Na} with the phospholipid phosphatidylcholine. The analysis of the resulting supramolecular structures using dynamic light scattering and cryo-transmission electron microscopy has shown the formation of different aggregates depending on the metallosurfactant/phospholipid ratio, as well as a significantly different behaviour between the two studied metallosurfactants. Mixed vesicles, with properties very similar to liposomes, can be obtained with both compounds, and are called metallosomes. The formation of the mixed aggregates has also been studied by microfluidics using MeOH and EtOH as organic solvents, and it has been observed that the size of the aggregates is strongly dependent on the organic solvent used. In order to analyse the viability of these mixed systems as CO Releasing Molecules (CORMs) for biomedical applications, the CO release was studied by FT-IR spectroscopy, showing that they behave as photo-CORMs with visible and ultraviolet light. Toxicity studies of the different mixed aggregate systems have shown that metallosomes exhibit a very low toxicity, similar to liposomes that do not contain metallosurfactants, which is well below the results observed for pure metallosurfactants. Micro-FTIR microscopy using synchrotron radiation has shown the presence of metallosurfactants in cells. The results of this study show the influence of the length of the hydrocarbon chain on the properties of these mixed systems, compared with previously reported data.",
keywords = "metallosurfactants, phospholipids, dynamic light scattering",
author = "M. Mar{\'i}n-Garc{\'i}a and N. Benseny-Cases and M. Camacho and Y. Perrie and J. Suades and R. Barnadas-Rodr{\'i}guez",
year = "2018",
month = "6",
day = "28",
doi = "10.1039/c8dt01584h",
language = "English",
journal = "Dalton Transactions",
issn = "1477-9226",

}

Metallosomes for biomedical applications by mixing molybdenum carbonyl metallosurfactants and phospholipids. / Marín-García, M.; Benseny-Cases, N.; Camacho, M.; Perrie, Y.; Suades, J.; Barnadas-Rodríguez, R.

In: Dalton Transactions, 28.06.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Metallosomes for biomedical applications by mixing molybdenum carbonyl metallosurfactants and phospholipids

AU - Marín-García, M.

AU - Benseny-Cases, N.

AU - Camacho, M.

AU - Perrie, Y.

AU - Suades, J.

AU - Barnadas-Rodríguez, R.

PY - 2018/6/28

Y1 - 2018/6/28

N2 - New supramolecular systems have been prepared by mixing molybdenum organometallic metallosurfactants M(CO)5L and M(CO)4L2 {L = Ph2P(CH2)6SO3Na} with the phospholipid phosphatidylcholine. The analysis of the resulting supramolecular structures using dynamic light scattering and cryo-transmission electron microscopy has shown the formation of different aggregates depending on the metallosurfactant/phospholipid ratio, as well as a significantly different behaviour between the two studied metallosurfactants. Mixed vesicles, with properties very similar to liposomes, can be obtained with both compounds, and are called metallosomes. The formation of the mixed aggregates has also been studied by microfluidics using MeOH and EtOH as organic solvents, and it has been observed that the size of the aggregates is strongly dependent on the organic solvent used. In order to analyse the viability of these mixed systems as CO Releasing Molecules (CORMs) for biomedical applications, the CO release was studied by FT-IR spectroscopy, showing that they behave as photo-CORMs with visible and ultraviolet light. Toxicity studies of the different mixed aggregate systems have shown that metallosomes exhibit a very low toxicity, similar to liposomes that do not contain metallosurfactants, which is well below the results observed for pure metallosurfactants. Micro-FTIR microscopy using synchrotron radiation has shown the presence of metallosurfactants in cells. The results of this study show the influence of the length of the hydrocarbon chain on the properties of these mixed systems, compared with previously reported data.

AB - New supramolecular systems have been prepared by mixing molybdenum organometallic metallosurfactants M(CO)5L and M(CO)4L2 {L = Ph2P(CH2)6SO3Na} with the phospholipid phosphatidylcholine. The analysis of the resulting supramolecular structures using dynamic light scattering and cryo-transmission electron microscopy has shown the formation of different aggregates depending on the metallosurfactant/phospholipid ratio, as well as a significantly different behaviour between the two studied metallosurfactants. Mixed vesicles, with properties very similar to liposomes, can be obtained with both compounds, and are called metallosomes. The formation of the mixed aggregates has also been studied by microfluidics using MeOH and EtOH as organic solvents, and it has been observed that the size of the aggregates is strongly dependent on the organic solvent used. In order to analyse the viability of these mixed systems as CO Releasing Molecules (CORMs) for biomedical applications, the CO release was studied by FT-IR spectroscopy, showing that they behave as photo-CORMs with visible and ultraviolet light. Toxicity studies of the different mixed aggregate systems have shown that metallosomes exhibit a very low toxicity, similar to liposomes that do not contain metallosurfactants, which is well below the results observed for pure metallosurfactants. Micro-FTIR microscopy using synchrotron radiation has shown the presence of metallosurfactants in cells. The results of this study show the influence of the length of the hydrocarbon chain on the properties of these mixed systems, compared with previously reported data.

KW - metallosurfactants

KW - phospholipids

KW - dynamic light scattering

UR - http://pubs.rsc.org/en/journals/journalissues/dt

U2 - 10.1039/c8dt01584h

DO - 10.1039/c8dt01584h

M3 - Article

JO - Dalton Transactions

T2 - Dalton Transactions

JF - Dalton Transactions

SN - 1477-9226

ER -