Abstract
The scope of neutral organic super-electron donors as reducing agents has been extended to include the reductive cleavage of N-O bonds in Weinreb amides. This methodology proved to be applicable to a large array of substrates to afford their reduced counterparts in good to excellent yields. The variation in reactivity within the set of tested amides is rationalised.
| Original language | English |
|---|---|
| Pages (from-to) | 2132-2136 |
| Number of pages | 4 |
| Journal | Synlett |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - 22 Aug 2008 |
Keywords
- electron transfer
- Weinreb amide
- reduction
- pyridinylidene
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Dive into the research topics of 'Metal-free reductive cleavage of N-O bonds in Weinreb amides by an organic neutral super-electron donor'. Together they form a unique fingerprint.Projects
- 2 Finished
-
Physical Organic Chemistry: Opportunities In Synthesis, Materials And Pharmaceuticals (Science And Innovation Award)
Murphy, J. (Principal Investigator), Coombs, G. (Co-investigator), Ferguson, A. (Co-investigator) & Florence, A. (Co-investigator)
Scottish Funding Council SFC, EPSRC (Engineering and Physical Sciences Research Council)
1/09/07 → 30/10/12
Project: Research
-
New horizons in organic electron transfer
Murphy, J. (Principal Investigator)
EPSRC (Engineering and Physical Sciences Research Council)
1/10/06 → 30/09/09
Project: Research
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