Metal-free reductive cleavage of N-O bonds in Weinreb amides by an organic neutral super-electron donor

S.P.Y. Cutulic, J.A. Murphy, H. Farwaha, S.Z. Zhou, E. Chrystal

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The scope of neutral organic super-electron donors as reducing agents has been extended to include the reductive cleavage of N-O bonds in Weinreb amides. This methodology proved to be applicable to a large array of substrates to afford their reduced counterparts in good to excellent yields. The variation in reactivity within the set of tested amides is rationalised.
Original languageEnglish
Pages (from-to)2132-2136
Number of pages4
JournalSynlett
Issue number14
DOIs
Publication statusPublished - 22 Aug 2008

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Amides
Metals
Electrons
Reducing Agents
Substrates

Keywords

  • electron transfer
  • Weinreb amide
  • reduction
  • pyridinylidene

Cite this

Cutulic, S.P.Y. ; Murphy, J.A. ; Farwaha, H. ; Zhou, S.Z. ; Chrystal, E. / Metal-free reductive cleavage of N-O bonds in Weinreb amides by an organic neutral super-electron donor. In: Synlett. 2008 ; No. 14. pp. 2132-2136.
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Metal-free reductive cleavage of N-O bonds in Weinreb amides by an organic neutral super-electron donor. / Cutulic, S.P.Y.; Murphy, J.A.; Farwaha, H.; Zhou, S.Z.; Chrystal, E.

In: Synlett, No. 14, 22.08.2008, p. 2132-2136.

Research output: Contribution to journalArticle

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AU - Chrystal, E.

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KW - pyridinylidene

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