Metal-free reductive cleavage of N-O bonds in Weinreb amides by an organic neutral super-electron donor

S.P.Y. Cutulic, J.A. Murphy, H. Farwaha, S.Z. Zhou, E. Chrystal

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The scope of neutral organic super-electron donors as reducing agents has been extended to include the reductive cleavage of N-O bonds in Weinreb amides. This methodology proved to be applicable to a large array of substrates to afford their reduced counterparts in good to excellent yields. The variation in reactivity within the set of tested amides is rationalised.
Original languageEnglish
Pages (from-to)2132-2136
Number of pages4
JournalSynlett
Issue number14
DOIs
Publication statusPublished - 22 Aug 2008

Keywords

  • electron transfer
  • Weinreb amide
  • reduction
  • pyridinylidene

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