Metal-free C-H functionalization strategies for heterocyclic building blocks.

Achim Porzelle, Nicholas C. O. Tomkinson

Research output: Contribution to conferenceOtherpeer-review


A major interest in synthetic research is the controlled introduction and elaboration of new carbon-heteroatom bonds for the synthesis of arom. and heteroarom. scaffolds. Recently, C-H functionalization strategies have provided important contributions to the available methods. Although efficient and practical, the majority of these processes rely on activation with transition metals. The development of a metal-free methodol. to activate arom. rings would significantly augment the available methods and provide a valuable synthetic alternative. Within the poster we present a versatile rearrangement strategy to form new aryl-heteroatom bonds providing access to hydroxyl-, amino- and mercapto-anilines. The N-aryl hydroxylamine substrates for the rearrangement process (1) can easily be accessed from nitroarenes through a one-pot redn./protection sequence. The products from this technol. provide fundamental building blocks for the prepn. of a variety of pharmacol. important heterocyclic compds. [on SciFinder(R)]
Original languageEnglish
Publication statusPublished - 16 Aug 2009
Event238th ACS National Meeting - Washington, United States
Duration: 16 Aug 200920 Aug 2009


Conference238th ACS National Meeting
Country/TerritoryUnited States


Dive into the research topics of 'Metal-free C-H functionalization strategies for heterocyclic building blocks.'. Together they form a unique fingerprint.

Cite this