Abstract
A major interest in synthetic research is the controlled introduction and elaboration of new carbon-heteroatom bonds for the synthesis of arom. and heteroarom. scaffolds. Recently, C-H functionalization strategies have provided important contributions to the available methods. Although efficient and practical, the majority of these processes rely on activation with transition metals. The development of a metal-free methodol. to activate arom. rings would significantly augment the available methods and provide a valuable synthetic alternative. Within the poster we present a versatile rearrangement strategy to form new aryl-heteroatom bonds providing access to hydroxyl-, amino- and mercapto-anilines. The N-aryl hydroxylamine substrates for the rearrangement process (1) can easily be accessed from nitroarenes through a one-pot redn./protection sequence. The products from this technol. provide fundamental building blocks for the prepn. of a variety of pharmacol. important heterocyclic compds. [on SciFinder(R)]
Original language | English |
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Pages | ORGN-723 |
Publication status | Published - 16 Aug 2009 |
Event | 238th ACS National Meeting - Washington, United States Duration: 16 Aug 2009 → 20 Aug 2009 |
Conference
Conference | 238th ACS National Meeting |
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Country/Territory | United States |
City | Washington |
Period | 16/08/09 → 20/08/09 |