Projects per year
The challenges of developing sustainable methods of carbon-carbon bond formation remains a topic of considerable importance in synthetic chemistry. Capitalizing on the highly reactive nature of the nitrile imine 1,3-dipole, we have developed a novel metal-free coupling of this species with aryl boronic acids. Photochemical generation of a nitrile imine intermediate and trapping with a palette of boronic acids enabled rapid and facile access to a broad library of more than 25 hydrazone derivatives in up to 92 % yield, forming a carbon-carbon bond in a metal free fashion. This represents the first reported example of direct reaction between boronic acids and a 1,3-dipole.
- formation of carbon-carbon bonds
- C-C bonds
- reaction manifolds
- nitrillium betaine
- nitrile imine (NI)
FingerprintDive into the research topics of 'Metal free C-C bond formation via coupling of nitrile imines and boronic acids'. Together they form a unique fingerprint.
- 1 Finished
1/10/16 → 26/08/20
Project: Research Studentship Case - Internally allocated