Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in the search potential antimicrobial drugs

Ahmed Fares Tawfike, Ruangelie Edrada-Ebel, Roth Tate, Marc Diederich, Marc Schumacher, Richard Sawadogo, Carol Clements, Louise Young

Research output: Contribution to conferencePoster

Abstract

This study involved bioassay guided chromatographic isolation of three new natural compounds with 40 known bio-active metabolites from three endophytic fungi from different Egyptian medicinal plants. Identification of the strain has been achieved through molecular biological methods. Metabolomic profiling, using 2D-NMR and HR-ESIFTMS were done at different stages of the growth phase for both solid and liquid culture media. Dereplication studies were accomplished by utilizing the Mzmine software with the AntiBase database. The chemometric algorithms using SIMCA-P+ software were used to compare the active and inactive extracts and/or fractions in order to early predict the bioactive metabolites

Conference

ConferenceMetabolomics 2014
CountryJapan
CityTsuruoka
Period23/06/1426/06/14
Other10th Annual International Conference of the Metabolomics Society. The Official Joint Conference of the Metabolomics Society and Plant Metabolomics Platform.
Internet address

Fingerprint

Metabolomics
Medicinal Plants
Software
Biological Assay
Pharmaceutical Preparations
Culture Media
Fungi
Databases
Growth

Keywords

  • bioactive metabolites
  • Egyptian medicinal plants
  • anti cancer drugs

Cite this

Tawfike, A. F., Edrada-Ebel, R., Tate, R., Diederich, M., Schumacher, M., Sawadogo, R., ... Young, L. (2014). Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in the search potential antimicrobial drugs. 116. Poster session presented at Metabolomics 2014, Tsuruoka, Japan.
Tawfike, Ahmed Fares ; Edrada-Ebel, Ruangelie ; Tate, Roth ; Diederich, Marc ; Schumacher, Marc ; Sawadogo, Richard ; Clements, Carol ; Young, Louise. / Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in the search potential antimicrobial drugs. Poster session presented at Metabolomics 2014, Tsuruoka, Japan.1 p.
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abstract = "This study involved bioassay guided chromatographic isolation of three new natural compounds with 40 known bio-active metabolites from three endophytic fungi from different Egyptian medicinal plants. Identification of the strain has been achieved through molecular biological methods. Metabolomic profiling, using 2D-NMR and HR-ESIFTMS were done at different stages of the growth phase for both solid and liquid culture media. Dereplication studies were accomplished by utilizing the Mzmine software with the AntiBase database. The chemometric algorithms using SIMCA-P+ software were used to compare the active and inactive extracts and/or fractions in order to early predict the bioactive metabolites",
keywords = "bioactive metabolites, Egyptian medicinal plants, anti cancer drugs",
author = "Tawfike, {Ahmed Fares} and Ruangelie Edrada-Ebel and Roth Tate and Marc Diederich and Marc Schumacher and Richard Sawadogo and Carol Clements and Louise Young",
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Tawfike, AF, Edrada-Ebel, R, Tate, R, Diederich, M, Schumacher, M, Sawadogo, R, Clements, C & Young, L 2014, 'Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in the search potential antimicrobial drugs' Metabolomics 2014, Tsuruoka, Japan, 23/06/14 - 26/06/14, pp. 116.

Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in the search potential antimicrobial drugs. / Tawfike, Ahmed Fares; Edrada-Ebel, Ruangelie; Tate, Roth; Diederich, Marc; Schumacher, Marc; Sawadogo, Richard; Clements, Carol; Young, Louise.

2014. 116 Poster session presented at Metabolomics 2014, Tsuruoka, Japan.

Research output: Contribution to conferencePoster

TY - CONF

T1 - Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in the search potential antimicrobial drugs

AU - Tawfike, Ahmed Fares

AU - Edrada-Ebel, Ruangelie

AU - Tate, Roth

AU - Diederich, Marc

AU - Schumacher, Marc

AU - Sawadogo, Richard

AU - Clements, Carol

AU - Young, Louise

PY - 2014/6/23

Y1 - 2014/6/23

N2 - This study involved bioassay guided chromatographic isolation of three new natural compounds with 40 known bio-active metabolites from three endophytic fungi from different Egyptian medicinal plants. Identification of the strain has been achieved through molecular biological methods. Metabolomic profiling, using 2D-NMR and HR-ESIFTMS were done at different stages of the growth phase for both solid and liquid culture media. Dereplication studies were accomplished by utilizing the Mzmine software with the AntiBase database. The chemometric algorithms using SIMCA-P+ software were used to compare the active and inactive extracts and/or fractions in order to early predict the bioactive metabolites

AB - This study involved bioassay guided chromatographic isolation of three new natural compounds with 40 known bio-active metabolites from three endophytic fungi from different Egyptian medicinal plants. Identification of the strain has been achieved through molecular biological methods. Metabolomic profiling, using 2D-NMR and HR-ESIFTMS were done at different stages of the growth phase for both solid and liquid culture media. Dereplication studies were accomplished by utilizing the Mzmine software with the AntiBase database. The chemometric algorithms using SIMCA-P+ software were used to compare the active and inactive extracts and/or fractions in order to early predict the bioactive metabolites

KW - bioactive metabolites

KW - Egyptian medicinal plants

KW - anti cancer drugs

UR - http://www.metabolomics2014.org/

M3 - Poster

SP - 116

ER -

Tawfike AF, Edrada-Ebel R, Tate R, Diederich M, Schumacher M, Sawadogo R et al. Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in the search potential antimicrobial drugs. 2014. Poster session presented at Metabolomics 2014, Tsuruoka, Japan.