Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in the search potential antimicrobial drugs

Ahmed Fares Tawfike; Ruangelie Edrada-Ebel; Roth Tate; Marc Diederich; Marc Schumacher; Richard Sawadogo; Carol Clements; Louise Young

Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in the search potential antimicrobial drugs

Ahmed Fares Tawfike, Ruangelie Edrada-Ebel, Roth Tate, Marc Diederich, Marc Schumacher, Richard Sawadogo, Carol Clements, Louise Young

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to conference › Poster › peer-review

Abstract

This study involved bioassay guided chromatographic isolation of three new natural compounds with 40 known bio-active metabolites from three endophytic fungi from different Egyptian medicinal plants. Identification of the strain has been achieved through molecular biological methods. Metabolomic profiling, using 2D-NMR and HR-ESIFTMS were done at different stages of the growth phase for both solid and liquid culture media. Dereplication studies were accomplished by utilizing the Mzmine software with the AntiBase database. The chemometric algorithms using SIMCA-P+ software were used to compare the active and inactive extracts and/or fractions in order to early predict the bioactive metabolites

Original language	English
Pages	116
Number of pages	1
Publication status	Published - 23 Jun 2014
Event	Metabolomics 2014 - Daiichi Hotel Tsuruoka and Marica/Washington Hotel, Tsuruoka, Japan Duration: 23 Jun 2014 → 26 Jun 2014 http://metabolomics2014.org/

Conference

Conference	Metabolomics 2014
Country	Japan
City	Tsuruoka
Period	23/06/14 → 26/06/14
Other	10th Annual International Conference of the Metabolomics Society. The Official Joint Conference of the Metabolomics Society and Plant Metabolomics Platform.
Internet address	http://metabolomics2014.org/

Keywords

bioactive metabolites
Egyptian medicinal plants
anti cancer drugs

Access to Document

http://www.metabolomics2014.org/

Cite this

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title = "Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in the search potential antimicrobial drugs",

abstract = "This study involved bioassay guided chromatographic isolation of three new natural compounds with 40 known bio-active metabolites from three endophytic fungi from different Egyptian medicinal plants. Identification of the strain has been achieved through molecular biological methods. Metabolomic profiling, using 2D-NMR and HR-ESIFTMS were done at different stages of the growth phase for both solid and liquid culture media. Dereplication studies were accomplished by utilizing the Mzmine software with the AntiBase database. The chemometric algorithms using SIMCA-P+ software were used to compare the active and inactive extracts and/or fractions in order to early predict the bioactive metabolites",

keywords = "bioactive metabolites, Egyptian medicinal plants, anti cancer drugs",

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year = "2014",

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Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in the search potential antimicrobial drugs. / Tawfike, Ahmed Fares; Edrada-Ebel, Ruangelie ; Tate, Roth; Diederich, Marc; Schumacher, Marc; Sawadogo, Richard; Clements, Carol; Young, Louise.

2014. 116 Poster session presented at Metabolomics 2014, Tsuruoka, Japan.

Research output: Contribution to conference › Poster › peer-review

TY - CONF

T1 - Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in the search potential antimicrobial drugs

AU - Tawfike, Ahmed Fares

AU - Edrada-Ebel, Ruangelie

AU - Tate, Roth

AU - Diederich, Marc

AU - Schumacher, Marc

AU - Sawadogo, Richard

AU - Clements, Carol

AU - Young, Louise

PY - 2014/6/23

Y1 - 2014/6/23

N2 - This study involved bioassay guided chromatographic isolation of three new natural compounds with 40 known bio-active metabolites from three endophytic fungi from different Egyptian medicinal plants. Identification of the strain has been achieved through molecular biological methods. Metabolomic profiling, using 2D-NMR and HR-ESIFTMS were done at different stages of the growth phase for both solid and liquid culture media. Dereplication studies were accomplished by utilizing the Mzmine software with the AntiBase database. The chemometric algorithms using SIMCA-P+ software were used to compare the active and inactive extracts and/or fractions in order to early predict the bioactive metabolites

AB - This study involved bioassay guided chromatographic isolation of three new natural compounds with 40 known bio-active metabolites from three endophytic fungi from different Egyptian medicinal plants. Identification of the strain has been achieved through molecular biological methods. Metabolomic profiling, using 2D-NMR and HR-ESIFTMS were done at different stages of the growth phase for both solid and liquid culture media. Dereplication studies were accomplished by utilizing the Mzmine software with the AntiBase database. The chemometric algorithms using SIMCA-P+ software were used to compare the active and inactive extracts and/or fractions in order to early predict the bioactive metabolites

KW - bioactive metabolites

KW - Egyptian medicinal plants

KW - anti cancer drugs

UR - http://www.metabolomics2014.org/

M3 - Poster

SP - 116

T2 - Metabolomics 2014

Y2 - 23 June 2014 through 26 June 2014

ER -