Metabolic sensing using fluorescence

David J.S. Birch; Ashok Ganesan; Jan Karolin

doi:10.1016/j.synthmet.2005.09.025

Metabolic sensing using fluorescence

David J.S. Birch, Ashok Ganesan, Jan Karolin

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

With a view to assessing the current boundaries of non-invasive sensing of metabolites we compare the photophysical properties of melanin nanoparticles in vivo, size selected in natural form from Sepia officinalis extracted from cuttlefish, and synthesised from L-dihydoxyphenylalanine (DOPA) in water pools of reverse micelles. The fluorescence emission spectra and excited state decay components correlate well with the particle size. Recent developments in optical technology are discussed in the context of the formidable challenges and opportunities for metabolic sensing presented by endogenous fluorophores.

Original language	English
Pages (from-to)	410-413
Number of pages	4
Journal	Synthetic Metals
Volume	155
Issue number	2
DOIs	https://doi.org/10.1016/j.synthmet.2005.09.025
Publication status	Published - 15 Nov 2005

Keywords

self-organisation in macromolecules
optical absorption
emission spectroscopy
time-resolved fast spectroscopy

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10.1016/j.synthmet.2005.09.025

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@article{d08f2303296745d2930d42c3bd4ba694,

title = "Metabolic sensing using fluorescence",

abstract = "With a view to assessing the current boundaries of non-invasive sensing of metabolites we compare the photophysical properties of melanin nanoparticles in vivo, size selected in natural form from Sepia officinalis extracted from cuttlefish, and synthesised from L-dihydoxyphenylalanine (DOPA) in water pools of reverse micelles. The fluorescence emission spectra and excited state decay components correlate well with the particle size. Recent developments in optical technology are discussed in the context of the formidable challenges and opportunities for metabolic sensing presented by endogenous fluorophores.",

keywords = "self-organisation in macromolecules, optical absorption, emission spectroscopy, time-resolved fast spectroscopy",

author = "Birch, {David J.S.} and Ashok Ganesan and Jan Karolin",

note = "6th International Topical Conference on Optical Probes of Conjugated Polymers and Biosystems, Bangalore, INDIA, JAN 04-08, 2005",

year = "2005",

month = nov,

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doi = "10.1016/j.synthmet.2005.09.025",

language = "English",

volume = "155",

pages = "410--413",

journal = "Synthetic Metals",

issn = "0379-6779",

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TY - JOUR

T1 - Metabolic sensing using fluorescence

AU - Birch, David J.S.

AU - Ganesan, Ashok

AU - Karolin, Jan

N1 - 6th International Topical Conference on Optical Probes of Conjugated Polymers and Biosystems, Bangalore, INDIA, JAN 04-08, 2005

PY - 2005/11/15

Y1 - 2005/11/15

N2 - With a view to assessing the current boundaries of non-invasive sensing of metabolites we compare the photophysical properties of melanin nanoparticles in vivo, size selected in natural form from Sepia officinalis extracted from cuttlefish, and synthesised from L-dihydoxyphenylalanine (DOPA) in water pools of reverse micelles. The fluorescence emission spectra and excited state decay components correlate well with the particle size. Recent developments in optical technology are discussed in the context of the formidable challenges and opportunities for metabolic sensing presented by endogenous fluorophores.

AB - With a view to assessing the current boundaries of non-invasive sensing of metabolites we compare the photophysical properties of melanin nanoparticles in vivo, size selected in natural form from Sepia officinalis extracted from cuttlefish, and synthesised from L-dihydoxyphenylalanine (DOPA) in water pools of reverse micelles. The fluorescence emission spectra and excited state decay components correlate well with the particle size. Recent developments in optical technology are discussed in the context of the formidable challenges and opportunities for metabolic sensing presented by endogenous fluorophores.

KW - self-organisation in macromolecules

KW - optical absorption

KW - emission spectroscopy

KW - time-resolved fast spectroscopy

U2 - 10.1016/j.synthmet.2005.09.025

DO - 10.1016/j.synthmet.2005.09.025

M3 - Article

SN - 0379-6779

VL - 155

SP - 410

EP - 413

JO - Synthetic Metals

JF - Synthetic Metals

IS - 2

ER -

Metabolic sensing using fluorescence

Abstract

Keywords

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