Meningo-encephalitis accompanying retinochoroiditis in a murine model of congenital toxoplasmosis

J. Hay, D.I. Graham, W.M. Hutchison, J.C. Siim

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


A histopathological study of the brains of adult mice infected in utero with Toxoplasma gondii and presenting manifestations of ocular toxoplasmosis is reported. All brains contained Toxoplasma tissue cysts. A sub-acute/chronic meningo-encephalitis was the main feature of the inflammatory response in the brain. Microscopical features suggest that autoimmune processes may play a part in the disease. We suggest that our mouse model will provide a simple and inexpensive tool for the investigation of histopathological processes in the CNS resulting from congenital Toxoplasma infection.
Original languageEnglish
Pages (from-to)21-29
Number of pages9
JournalAnnals of Tropical Medicine and Parasitology
Issue number1
Publication statusPublished - 1985


  • meningo-encephalitis
  • retinochoroiditis
  • murine model
  • congenital toxoplasmosis
  • mice
  • brains


Dive into the research topics of 'Meningo-encephalitis accompanying retinochoroiditis in a murine model of congenital toxoplasmosis'. Together they form a unique fingerprint.

Cite this