Meningo-encephalitis accompanying retinochoroiditis in a murine model of congenital toxoplasmosis

J. Hay, D.I. Graham, W.M. Hutchison, J.C. Siim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A histopathological study of the brains of adult mice infected in utero with Toxoplasma gondii and presenting manifestations of ocular toxoplasmosis is reported. All brains contained Toxoplasma tissue cysts. A sub-acute/chronic meningo-encephalitis was the main feature of the inflammatory response in the brain. Microscopical features suggest that autoimmune processes may play a part in the disease. We suggest that our mouse model will provide a simple and inexpensive tool for the investigation of histopathological processes in the CNS resulting from congenital Toxoplasma infection.
LanguageEnglish
Pages21-29
Number of pages9
JournalAnnals of Tropical Medicine and Parasitology
Volume79
Issue number1
Publication statusPublished - 1985

Fingerprint

Congenital Toxoplasmosis
Encephalitis
Toxoplasma
Brain
Ocular Toxoplasmosis
Cysts

Keywords

  • meningo-encephalitis
  • retinochoroiditis
  • murine model
  • congenital toxoplasmosis
  • mice
  • brains

Cite this

Hay, J. ; Graham, D.I. ; Hutchison, W.M. ; Siim, J.C. / Meningo-encephalitis accompanying retinochoroiditis in a murine model of congenital toxoplasmosis. In: Annals of Tropical Medicine and Parasitology. 1985 ; Vol. 79, No. 1. pp. 21-29.
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Meningo-encephalitis accompanying retinochoroiditis in a murine model of congenital toxoplasmosis. / Hay, J.; Graham, D.I.; Hutchison, W.M.; Siim, J.C.

In: Annals of Tropical Medicine and Parasitology, Vol. 79, No. 1, 1985, p. 21-29.

Research output: Contribution to journalArticle

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AU - Hay, J.

AU - Graham, D.I.

AU - Hutchison, W.M.

AU - Siim, J.C.

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