Meningo-encephalitis accompanying retinochoroiditis in a murine model of congenital toxoplasmosis

J. Hay, D.I. Graham, W.M. Hutchison, J.C. Siim

Research output: Contribution to journalArticle

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Abstract

A histopathological study of the brains of adult mice infected in utero with Toxoplasma gondii and presenting manifestations of ocular toxoplasmosis is reported. All brains contained Toxoplasma tissue cysts. A sub-acute/chronic meningo-encephalitis was the main feature of the inflammatory response in the brain. Microscopical features suggest that autoimmune processes may play a part in the disease. We suggest that our mouse model will provide a simple and inexpensive tool for the investigation of histopathological processes in the CNS resulting from congenital Toxoplasma infection.
Original languageEnglish
Pages (from-to)21-29
Number of pages9
JournalAnnals of Tropical Medicine and Parasitology
Volume79
Issue number1
Publication statusPublished - 1985

Keywords

  • meningo-encephalitis
  • retinochoroiditis
  • murine model
  • congenital toxoplasmosis
  • mice
  • brains

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