A histopathological study of the brains of adult mice infected in utero with Toxoplasma gondii and presenting manifestations of ocular toxoplasmosis is reported. All brains contained Toxoplasma tissue cysts. A sub-acute/chronic meningo-encephalitis was the main feature of the inflammatory response in the brain. Microscopical features suggest that autoimmune processes may play a part in the disease. We suggest that our mouse model will provide a simple and inexpensive tool for the investigation of histopathological processes in the CNS resulting from congenital Toxoplasma infection.
|Number of pages||9|
|Journal||Annals of Tropical Medicine and Parasitology|
|Publication status||Published - 1985|
- murine model
- congenital toxoplasmosis
Hay, J., Graham, D. I., Hutchison, W. M., & Siim, J. C. (1985). Meningo-encephalitis accompanying retinochoroiditis in a murine model of congenital toxoplasmosis. Annals of Tropical Medicine and Parasitology, 79(1), 21-29.