Abstract
A histopathological study of the brains of adult mice infected in utero with Toxoplasma gondii and presenting manifestations of ocular toxoplasmosis is reported. All brains contained Toxoplasma tissue cysts. A sub-acute/chronic meningo-encephalitis was the main feature of the inflammatory response in the brain. Microscopical features suggest that autoimmune processes may play a part in the disease. We suggest that our mouse model will provide a simple and inexpensive tool for the investigation of histopathological processes in the CNS resulting from congenital Toxoplasma infection.
| Original language | English |
|---|---|
| Pages (from-to) | 21-29 |
| Number of pages | 9 |
| Journal | Annals of Tropical Medicine and Parasitology |
| Volume | 79 |
| Issue number | 1 |
| Publication status | Published - 1985 |
Keywords
- meningo-encephalitis
- retinochoroiditis
- murine model
- congenital toxoplasmosis
- mice
- brains
