Projects per year
Abstract
We have designed and implemented a compact, cost-efficient miniaturised light-sheet microscopy system based on optical microelectromechanical systems scanners and tunable lenses. The system occupies a footprint of 20 × 28 × 13 cm 3 and combines off-the-shelf optics and optomechanics with 3D-printed structural and optical elements, and an economically costed objective lens, excitation laser and camera. All-optical volume scanning enables imaging of 435 × 232 × 60 µm 3 volumes with 0.25 vps (volumes per second) and minimum lateral and axial resolution of 1.0 µm and 3.8 µm respectively. An open-top geometry allows imaging of samples on flat bottomed holders, allowing integration with microfluidic devices, multi-well plates and slide mounted samples, with applications envisaged in biomedical research and pre-clinical settings.
Original language | English |
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Article number | 14100 |
Number of pages | 11 |
Journal | Scientific Reports |
Volume | 11 |
Issue number | 1 |
DOIs | |
Publication status | Published - 8 Jul 2021 |
Keywords
- microelectromechanical system (MEMS)
- optomechanics
- light sheet microscopy
- fluorescence microscopy
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Dive into the research topics of 'MEMS enabled miniaturized light-sheet microscopy with all optical control'. Together they form a unique fingerprint.Projects
- 2 Finished
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MEMS-enabled miniaturised multimodal microscopy through pulsed structured illumination
Bauer, R. (Principal Investigator)
EPSRC (Engineering and Physical Sciences Research Council)
6/01/20 → 15/10/22
Project: Research
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Miniaturised 3D-printed biomedical imaging system using optical MEMS - RAE Fellowships (GCRF)
Bauer, R. (Principal Investigator)
Royal Academy of Engineering RAE
1/10/16 → 30/09/21
Project: Research Fellowship
Datasets
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MEMS enabled miniaturised light-sheet microscope characterisation data
Bakas, S. (Creator), Uttamchandani, D. (Creator) & Bauer, R. (Creator), University of Strathclyde, 17 Jun 2021
DOI: 10.15129/96b96f33-0956-4621-a203-282fa799e7ed
Dataset