MEMS-enabled label-free optical coherent scattering microscopy

Jay Christopher; Anna Miller; Annie Kroo; Charlie Butterworth; Olav Solgaard; Ralf Bauer

doi:10.1109/OMN70392.2026.11646808

MEMS-enabled label-free optical coherent scattering microscopy

Jay Christopher
, Anna Miller
, Annie Kroo
, Charlie Butterworth
, Olav Solgaard
, Ralf Bauer

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

Abstract

We enable rotating coherent scattering (ROCS) microscopy through a 2D scanning microelectromechanical systems (MEMS) micromirror to create a live-cell, label-free, high-resolution imaging system with real-time frame rates. The MEMS mirror allows for 100 Hz 2D circular scans which deliver oblique illumination necessary for coherent-scattering images characteristic of ROCS. Recovery of the scattering response of sub-resolution features additionally provides axial positioning to be extracted.

Original language	English
Title of host publication	2026 International Conference on Optical MEMS and Nanophotonics (OMN)
Publisher	IEEE
Number of pages	2
ISBN (Electronic)	979-8-3195-4424-7
ISBN (Print)	979-8-3195-4425-4
DOIs	https://doi.org/10.1109/OMN70392.2026.11646808
Publication status	Published - 14 Aug 2026
Event	IEEE International Conference on Optical MEMS and Nanophotonics 2026 - Hotel Sacacomie, Sacacomie, Canada Duration: 2 Aug 2026 → 6 Aug 2026 https://www.omn2026.org/

Publication series

Name	2026 International Conference on Optical MEMS and Nanophotonics (OMN)
Publisher	IEEE
ISSN (Print)	2160-5033
ISSN (Electronic)	2160-5041

Conference

Conference	IEEE International Conference on Optical MEMS and Nanophotonics 2026
Abbreviated title	OMN 2026
Country/Territory	Canada
City	Sacacomie
Period	2/08/26 → 6/08/26
Internet address	https://www.omn2026.org/

Keywords

MEMS
IRM
ROCS
label-free microscopy

Access to Document

10.1109/OMN70392.2026.11646808

Christopher-etal-2026-MEMS-enabled-label-free-optical-coherent-scattering-microscopyAccepted author manuscript, 264 KBLicence: CC BY 4.0

Cite this

@inproceedings{8ca5dcdd97e745c6ac9e62461ddbecb3,

title = "MEMS-enabled label-free optical coherent scattering microscopy",

abstract = "We enable rotating coherent scattering (ROCS) microscopy through a 2D scanning microelectromechanical systems (MEMS) micromirror to create a live-cell, label-free, high-resolution imaging system with real-time frame rates. The MEMS mirror allows for 100 Hz 2D circular scans which deliver oblique illumination necessary for coherent-scattering images characteristic of ROCS. Recovery of the scattering response of sub-resolution features additionally provides axial positioning to be extracted. ",

keywords = "MEMS, IRM, ROCS, label-free microscopy",

author = "Jay Christopher and Anna Miller and Annie Kroo and Charlie Butterworth and Olav Solgaard and Ralf Bauer",

year = "2026",

month = aug,

day = "14",

doi = "10.1109/OMN70392.2026.11646808",

language = "English",

isbn = "979-8-3195-4425-4",

series = "2026 International Conference on Optical MEMS and Nanophotonics (OMN)",

publisher = "IEEE",

booktitle = "2026 International Conference on Optical MEMS and Nanophotonics (OMN)",

note = "IEEE International Conference on Optical MEMS and Nanophotonics 2026, OMN 2026 ; Conference date: 02-08-2026 Through 06-08-2026",

url = "https://www.omn2026.org/",

}

Christopher, J, Miller, A, Kroo, A, Butterworth, C, Solgaard, O & Bauer, R 2026, MEMS-enabled label-free optical coherent scattering microscopy. in 2026 International Conference on Optical MEMS and Nanophotonics (OMN). 2026 International Conference on Optical MEMS and Nanophotonics (OMN), IEEE, IEEE International Conference on Optical MEMS and Nanophotonics 2026, Sacacomie, Quebec, Canada, 2/08/26. https://doi.org/10.1109/OMN70392.2026.11646808

TY - GEN

T1 - MEMS-enabled label-free optical coherent scattering microscopy

AU - Christopher, Jay

AU - Miller, Anna

AU - Kroo, Annie

AU - Butterworth, Charlie

AU - Solgaard, Olav

AU - Bauer, Ralf

PY - 2026/8/14

Y1 - 2026/8/14

N2 - We enable rotating coherent scattering (ROCS) microscopy through a 2D scanning microelectromechanical systems (MEMS) micromirror to create a live-cell, label-free, high-resolution imaging system with real-time frame rates. The MEMS mirror allows for 100 Hz 2D circular scans which deliver oblique illumination necessary for coherent-scattering images characteristic of ROCS. Recovery of the scattering response of sub-resolution features additionally provides axial positioning to be extracted.

AB - We enable rotating coherent scattering (ROCS) microscopy through a 2D scanning microelectromechanical systems (MEMS) micromirror to create a live-cell, label-free, high-resolution imaging system with real-time frame rates. The MEMS mirror allows for 100 Hz 2D circular scans which deliver oblique illumination necessary for coherent-scattering images characteristic of ROCS. Recovery of the scattering response of sub-resolution features additionally provides axial positioning to be extracted.

KW - MEMS

KW - IRM

KW - ROCS

KW - label-free microscopy

UR - https://www.omn2026.org/accueil

U2 - 10.1109/OMN70392.2026.11646808

DO - 10.1109/OMN70392.2026.11646808

M3 - Conference contribution book

SN - 979-8-3195-4425-4

T3 - 2026 International Conference on Optical MEMS and Nanophotonics (OMN)

BT - 2026 International Conference on Optical MEMS and Nanophotonics (OMN)

PB - IEEE

T2 - IEEE International Conference on Optical MEMS and Nanophotonics 2026

Y2 - 2 August 2026 through 6 August 2026

ER -

MEMS-enabled label-free optical coherent scattering microscopy

Abstract

Publication series

Conference

Keywords

Access to Document

Other files and links

Stanford - Strathclyde Quantum Growth Bridge

Stanford University

Cite this

MEMS-enabled label-free optical coherent scattering microscopy

Abstract

Publication series

Conference

Keywords

Access to Document

Other files and links

Projects

Stanford - Strathclyde Quantum Growth Bridge

Activities

Stanford University

Cite this