Memory binding and white matter integrity in familial alzheimer's disease

Mario A Parra, Heini Saarimäki, Mark E Bastin, Ana C Londoño, Lewis Pettit, Francisco Lopera, Sergio Della Sala, Sharon Abrahams

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Binding information in short-term and long-term memory are functions sensitive to Alzheimer's disease. They have been found to be affected in patients who meet criteria for familial Alzheimer's disease due to the mutation E280A of the PSEN1 gene. However, only short-term memory binding has been found to be affected in asymptomatic carriers of this mutation. The neural correlates of this dissociation are poorly understood. The present study used diffusion tensor magnetic resonance imaging to investigate whether the integrity of white matter structures could offer an account. A sample of 19 patients with familial Alzheimer's disease, 18 asymptomatic carriers and 21 non-carrier controls underwent diffusion tensor magnetic resonance imaging, neuropsychological and memory binding assessment. The short-term memory binding task required participants to detect changes across two consecutive screens displaying arrays of shapes, colours, or shape-colour bindings. The long-term memory binding task was a Paired Associates Learning Test. Performance on these tasks were entered into regression models. Relative to controls, patients with familial Alzheimer's disease performed poorly on both memory binding tasks. Asymptomatic carriers differed from controls only in the short-term memory binding task. White matter integrity explained poor memory binding performance only in patients with familial Alzheimer's disease. White matter water diffusion metrics from the frontal lobe accounted for poor performance on both memory binding tasks. Dissociations were found in the genu of corpus callosum which accounted for short-term memory binding impairments and in the hippocampal part of cingulum bundle which accounted for long-term memory binding deficits. The results indicate that white matter structures in the frontal and temporal lobes are vulnerable to the early stages of familial Alzheimer's disease and their damage is associated with impairments in two memory binding functions known to be markers for Alzheimer's disease.
LanguageEnglish
Pages1355-1369
Number of pages15
JournalBrain
Volume138
Issue number5
DOIs
Publication statusPublished - 1 May 2015

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Alzheimer Disease
Short-Term Memory
Long-Term Memory
Dissociative Disorders
Diffusion Magnetic Resonance Imaging
Frontal Lobe
Color
Paired-Associate Learning
Mutation
Corpus Callosum
Memory Disorders
Task Performance and Analysis
Temporal Lobe
White Matter
Water
Genes

Keywords

  • memory binding
  • white matter integrity
  • Alzheimer’s disease

Cite this

Parra, M. A., Saarimäki, H., Bastin, M. E., Londoño, A. C., Pettit, L., Lopera, F., ... Abrahams, S. (2015). Memory binding and white matter integrity in familial alzheimer's disease. Brain, 138(5), 1355-1369. https://doi.org/10.1093/brain/awv048
Parra, Mario A ; Saarimäki, Heini ; Bastin, Mark E ; Londoño, Ana C ; Pettit, Lewis ; Lopera, Francisco ; Della Sala, Sergio ; Abrahams, Sharon. / Memory binding and white matter integrity in familial alzheimer's disease. In: Brain. 2015 ; Vol. 138, No. 5. pp. 1355-1369.
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Parra, MA, Saarimäki, H, Bastin, ME, Londoño, AC, Pettit, L, Lopera, F, Della Sala, S & Abrahams, S 2015, 'Memory binding and white matter integrity in familial alzheimer's disease' Brain, vol. 138, no. 5, pp. 1355-1369. https://doi.org/10.1093/brain/awv048

Memory binding and white matter integrity in familial alzheimer's disease. / Parra, Mario A; Saarimäki, Heini; Bastin, Mark E; Londoño, Ana C; Pettit, Lewis; Lopera, Francisco; Della Sala, Sergio; Abrahams, Sharon.

In: Brain, Vol. 138, No. 5, 01.05.2015, p. 1355-1369.

Research output: Contribution to journalArticle

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T1 - Memory binding and white matter integrity in familial alzheimer's disease

AU - Parra, Mario A

AU - Saarimäki, Heini

AU - Bastin, Mark E

AU - Londoño, Ana C

AU - Pettit, Lewis

AU - Lopera, Francisco

AU - Della Sala, Sergio

AU - Abrahams, Sharon

N1 - © The Author (2015). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Binding information in short-term and long-term memory are functions sensitive to Alzheimer's disease. They have been found to be affected in patients who meet criteria for familial Alzheimer's disease due to the mutation E280A of the PSEN1 gene. However, only short-term memory binding has been found to be affected in asymptomatic carriers of this mutation. The neural correlates of this dissociation are poorly understood. The present study used diffusion tensor magnetic resonance imaging to investigate whether the integrity of white matter structures could offer an account. A sample of 19 patients with familial Alzheimer's disease, 18 asymptomatic carriers and 21 non-carrier controls underwent diffusion tensor magnetic resonance imaging, neuropsychological and memory binding assessment. The short-term memory binding task required participants to detect changes across two consecutive screens displaying arrays of shapes, colours, or shape-colour bindings. The long-term memory binding task was a Paired Associates Learning Test. Performance on these tasks were entered into regression models. Relative to controls, patients with familial Alzheimer's disease performed poorly on both memory binding tasks. Asymptomatic carriers differed from controls only in the short-term memory binding task. White matter integrity explained poor memory binding performance only in patients with familial Alzheimer's disease. White matter water diffusion metrics from the frontal lobe accounted for poor performance on both memory binding tasks. Dissociations were found in the genu of corpus callosum which accounted for short-term memory binding impairments and in the hippocampal part of cingulum bundle which accounted for long-term memory binding deficits. The results indicate that white matter structures in the frontal and temporal lobes are vulnerable to the early stages of familial Alzheimer's disease and their damage is associated with impairments in two memory binding functions known to be markers for Alzheimer's disease.

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Parra MA, Saarimäki H, Bastin ME, Londoño AC, Pettit L, Lopera F et al. Memory binding and white matter integrity in familial alzheimer's disease. Brain. 2015 May 1;138(5):1355-1369. https://doi.org/10.1093/brain/awv048